Woodhouse, A and Fernandez-Martos, CM and Atkinson, RAK and Hanson, KA and Collins, JM and O'Mara, AR and Terblanche, N and Skinner, MW and Vickers, JC and King, AE, Repeat propofol anesthesia does not exacerbate plaque deposition or synapse loss in APP/PS1 Alzheimer's disease mice, BMC Anesthesiology, 18, (1) Article 47. ISSN 1471-2253 (2018) [Refereed Article]
Methods: Six month-old amyloid precursor protein/presenilin 1 (APP/PS1) transgenic AD mice and control mice were exposed to 3 doses of propofol (200 mg/kg) or vehicle, delivered at monthly intervals.
Results: There was no difference in the extent of β-amyloid (Aβ) immunolabeled plaque deposition in APP/PS1 mice in vehicle versus propofol treatment groups. We also detected no difference in plaque-associated synapse loss in APP/PS1 mice following repeat propofol exposure relative to vehicle. Western blotting indicated that there was no difference in post-synaptic density protein 95, synaptophysin or glutamic acid decarboxylase 65/67 expression in control or APP/PS1 mice subjected to repeat propofol treatment relative to vehicle.
Conclusions: These data suggest that repeat propofol anesthesia may not exacerbate plaque deposition or associated synapse loss in AD. Interestingly, this data also provides some of the first evidence suggesting that repeat propofol exposure in adult wild-type mice does not result in robust long-term alterations in the levels of key excitatory and inhibitory synaptic markers.
|Item Type:||Refereed Article|
|Keywords:||Alzheimer’s disease, glutamic acid decarboxylase, synapse, synaptophysin, β-amyloid plaques|
|Research Division:||Medical and Health Sciences|
|Research Field:||Neurosciences not elsewhere classified|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Neurodegenerative Disorders Related to Ageing|
|Author:||Woodhouse, A (Dr Adele Woodhouse)|
|Author:||Fernandez-Martos, CM (Dr Carmen Fernandez-Martos)|
|Author:||Atkinson, RAK (Mrs Rachel Atkinson)|
|Author:||Hanson, KA (Miss Kelsey Hanson)|
|Author:||Collins, JM (Dr Jessica Collins)|
|Author:||O'Mara, AR (Mr Aidan O'Mara)|
|Author:||Terblanche, N (Dr Nico Terblanche)|
|Author:||Skinner, MW (Dr Marcus Skinner)|
|Author:||Vickers, JC (Professor James Vickers)|
|Author:||King, AE (Associate Professor Anna King)|
|Deposited By:||Menzies Institute for Medical Research|
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