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Associations between knee structural measures, circulating inflammatory factors and MMP13 in patients with knee osteoarthritis


Ruan, G and Xu, J and Wang, K and Wu, J and Zhu, Q and Ren, J and Bian, F and Chang, B and Bai, X and Han, W and Ding, C, Associations between knee structural measures, circulating inflammatory factors and MMP13 in patients with knee osteoarthritis, Osteoarthritis and Cartilage pp. 1-7. ISSN 1063-4584 (2018) [Refereed Article]

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DOI: doi:10.1016/j.joca.2018.05.003


Objective: To investigate cross-sectional associations between serum level of Matrix metalloproteinase (MMP)13 and knee structural measures and circulating inflammatory factors in patients with symptomatic knee osteoarthritis (OA).

Design: A total of 149 subjects with symptomatic knee OA were included. Magnetic resonance imaging was used to measure infrapatellar fat pad (IPFP) volume, IPFP signal intensity alternation, cartilage volume and cartilage defects. Knee radiography was used to assess radiographic OA using the Kellgren-Lawrence (K-L) grading system. Enzyme-linked immunosorbent assay was used to measure the serum levels of inflammatory factors and MMP13.

Results: In multivariable analyses, serum MMP13 was negatively associated with cartilage volume at patellar site (β: -32.94 mm3 per 10 ng/ml, P < 0.05), and positively associated with cartilage defect at medial femoral site (OR: 1.13 per 10 ng/ml, P < 0.05). Also, MMP13 was positively associated with K-L grading and IPFP signal intensity alteration (OR: 1.14 and 1.15 per 10 ng/ml, respectively, both P < 0.05), and negatively associated with IPFP volume (β: -0.34 cm3 per 10 ng/ml, P < 0.05). Furthermore, serum level of adiponectin was negatively associated serum MMP13 quartiles (OR: 0.66 per 10 μg/ml, P < 0.05), and serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-8 and IL-18 were positively associated with serum MMP13 quartiles (ORs: 1.01-1.18 per 10 pg/ml, all P < 0.05).

Conclusions: Serum level of MMP13 was associated with knee structural abnormalities as well as serum inflammatory factors. These suggest that systemic MMP13 may play a role in knee OA, and could be regulated by inflammatory factors.

Item Details

Item Type:Refereed Article
Keywords:inflammatory factors, magnetic resonance imaging, matrix metalloproteinases 13, osteoarthritis
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Rheumatology and Arthritis
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
Author:Han, W (Dr Weiyu Han)
Author:Ding, C (Professor Chang-Hai Ding)
ID Code:126465
Year Published:2018
Deposited By:Menzies Institute for Medical Research
Deposited On:2018-06-13
Last Modified:2018-06-13

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