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Late gestation immune activation increases IBA1-positive immunoreactivity levels in the corpus callosum of adult rat offspring
Citation
Duchatel, RJ and Meehan, CL and Harms, LR and Michie, PT and Bigland, MJ and Smith, DW and Walker, FR and Jobling, P and Hodgson, DM and Tooney, PA, Late gestation immune activation increases IBA1-positive immunoreactivity levels in the corpus callosum of adult rat offspring, Psychiatry research pp. 175-185. ISSN 0165-1781 (2018) [Refereed Article]
Copyright Statement
Crown Copyright 2018 Published by Elsevier B.V. All rights reserved.
DOI: doi:10.1016/j.psychres.2018.05.063
Abstract
Animal models of maternal immune activation study the effects of infection, an environmental risk factor for
schizophrenia, on brain development. Microglia activation and cytokine upregulation may have key roles in
schizophrenia neuropathology. We hypothesised that maternal immune activation induces changes in microglia
and cytokines in the brains of the adult offspring. Maternal immune activation was induced by injecting polyriboinosinic:polyribocytidylic
acid into pregnant rats on gestational day (GD) 10 or GD19, with brain tissue
collected from the offspring at adulthood. We observed no change in Iba1, Gfap, IL1-βand TNF-α mRNA levels in
the cingulate cortex (CC) in adult offspring exposed to maternal immune activation. Prenatal exposure to immune
activation had a significant main effect on microglial IBA1-positive immunoreactive material (IBA1+IRM)
in the corpus callosum; post-hoc analyses identified a significant increase in GD19 offspring, but not GD10. No
change in was observed in the CC. In contrast, maternal immune activation had a significant main effect on GFAP
+IRM in the CC at GD19 (not GD10); post-hoc analyses only identified a strong trend towards increased GFAP
+IRM in the GD19 offspring, with no white matter changes. This suggests late gestation maternal immune
activation causes subtle alterations to microglia and astrocytes in the adult offspring.
Item Details
Item Type: | Refereed Article |
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Keywords: | Schizophrenia, Microglia, astrocyte, Maternal immune activation, Cingulate cortex, Late gestation, Rat |
Research Division: | Psychology |
Research Group: | Biological psychology |
Research Field: | Behavioural neuroscience |
Objective Division: | Health |
Objective Group: | Public health (excl. specific population health) |
Objective Field: | Mental health |
UTAS Author: | Meehan, CL (Dr Crystal Meehan) |
ID Code: | 126390 |
Year Published: | 2018 |
Web of Science® Times Cited: | 23 |
Deposited By: | Psychology |
Deposited On: | 2018-06-07 |
Last Modified: | 2018-07-23 |
Downloads: | 0 |
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