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Mismatch negativity (MMN) in freely-moving rats with several experimental controls

Citation

Harms, L and Fulham, WR and Todd, J and Budd, TW and Hunter, M and Meehan, C and Penttonen, M and Schall, U and Zavitsanou, K and Hodgson, DM and Michie, PT, Mismatch negativity (MMN) in freely-moving rats with several experimental controls, PloS one pp. 1-16. ISSN 1932-6203 (2014) [Refereed Article]


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Copyright Statement

Copyright 2014 Harms et al. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) http://creativecommons.org/licenses/by/4.0/

DOI: doi:10.1371/journal.pone.0110892

Abstract

Mismatch negativity (MMN) is a scalp-recorded electrical potential that occurs in humans in response to an auditory stimulus that defies previously established patterns of regularity. MMN amplitude is reduced in people with schizophrenia. In this study, we aimed to develop a robust and replicable rat model of MMN, as a platform for a more thorough understanding of the neurobiology underlying MMN. One of the major concerns for animal models of MMN is whether the rodent brain is capable of producing a human-like MMN, which is not a consequence of neural adaptation to repetitive stimuli. We therefore tested several methods that have been used to control for adaptation and differential exogenous responses to stimuli within the oddball paradigm. Epidural electroencephalographic electrodes were surgically implanted over different cortical locations in adult rats. Encephalographic data were recorded using wireless telemetry while the freely-moving rats were presented with auditory oddball stimuli to assess mismatch responses. Three control sequences were utilized: the flip-flop control was used to control for differential responses to the physical characteristics of standards and deviants; the many standards control was used to control for differential adaptation, as was the cascade control. Both adaptation and adaptation-independent deviance detection were observed for high frequency (pitch), but not low frequency deviants. In addition, the many standards control method was found to be the optimal method for observing both adaptation effects and adaptation-independent mismatch responses in rats. Inconclusive results arose from the cascade control design as it is not yet clear whether rats can encode the complex pattern present in the control sequence. These data contribute to a growing body of evidence supporting the hypothesis that rat brain is indeed capable of exhibiting human-like MMN, and that the rat model is a viable platform for the further investigation of the MMN and its associated neurobiology.

Item Details

Item Type:Refereed Article
Keywords:mismatch negativity, EEG, Rat, deviance detection
Research Division:Psychology and Cognitive Sciences
Research Group:Psychology
Research Field:Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)
Objective Division:Health
Objective Group:Public Health (excl. Specific Population Health)
Objective Field:Mental Health
UTAS Author:Meehan, C (Dr Crystal Meehan)
ID Code:126386
Year Published:2014
Web of Science® Times Cited:37
Deposited By:Psychology
Deposited On:2018-06-07
Last Modified:2018-07-23
Downloads:88 View Download Statistics

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