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Auditory tones and foot-shock recapitulate spontaneous sub-threshold activity in basolateral amygdala principal neurons and interneurons

Citation

Windels, F and Yan, S and Stratton, PG and Sullivan, R and Crane, JW and Sah, P, Auditory tones and foot-shock recapitulate spontaneous sub-threshold activity in basolateral amygdala principal neurons and interneurons, PLoS one, 11, (5) Article e0155192. ISSN 1932-6203 (2016) [Refereed Article]


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Copyright Statement

Copyright 2016 Windels et al. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

DOI: doi:10.1371/journal.pone.0155192

Abstract

In quiescent states such as anesthesia and slow wave sleep, cortical networks show slow rhythmic synchronized activity. In sensory cortices this rhythmic activity shows a stereotypical pattern that is recapitulated by stimulation of the appropriate sensory modality. The amygdala receives sensory input from a variety of sources, and in anesthetized animals, neurons in the basolateral amygdala (BLA) show slow rhythmic synchronized activity. Extracellular field potential recordings show that these oscillations are synchronized with sensory cortex and the thalamus, with both the thalamus and cortex leading the BLA. Using whole-cell recording in vivo we show that the membrane potential of principal neurons spontaneously oscillates between up- and down-states. Footshock and auditory stimulation delivered during down-states evokes an up-state that fully recapitulates those occurring spontaneously. These results suggest that neurons in the BLA receive convergent input from networks of cortical neurons with slow oscillatory activity and that somatosensory and auditory stimulation can trigger activity in these same networks.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Central Nervous System
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
UTAS Author:Crane, JW (Dr James Crane)
ID Code:126382
Year Published:2016
Web of Science® Times Cited:3
Deposited By:Office of the School of Medicine
Deposited On:2018-06-07
Last Modified:2018-08-09
Downloads:66 View Download Statistics

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