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Association of childhood adiposity measures with adulthood knee cartilage defects and bone marrow lesions: a 25-year cohort study

Citation

Meng, T and Thayer, S and Venn, A and Wu, F and Cicuttini, F and March, L and Dwyer, T and Halliday, A and Cross, M and Laslett, LL and Jones, G and Ding, C and Antony, B, Association of childhood adiposity measures with adulthood knee cartilage defects and bone marrow lesions: a 25-year cohort study, Osteoarthritis and Cartilage, 26, (8) pp. 1055-1062. ISSN 1063-4584 (2018) [Refereed Article]


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Copyright Statement

2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/

DOI: doi:10.1016/j.joca.2018.05.008

Abstract

Objective: To describe the associations between childhood adiposity measures and adulthood knee cartilage defects and bone marrow lesions (BMLs) measured 25 years later.

Methods: 327 participants from the Australian Schools Health and Fitness Survey (ASHFS) of 1985 (aged 7-15 years) were followed up 25 years later (aged 31-41 years). Childhood measures (weight, height and skinfolds) were collected in 1985. Body mass index (BMI), overweight status and fat mass were calculated. Participants underwent 1.5T knee magnetic resonance imaging (MRI) during 2008-2010, and cartilage defects and BMLs were scored from knee MRI scans. Log binomial regressions were used to examine the associations.

Results: Among 327 participants (47.1% females), 21 (6.4%) were overweight in childhood. Childhood adiposity measures were associated with the increased risk of adulthood patellar cartilage defects (Weight relative risk (RR) 1.05/kg, 95% confidence interval (CI) 1.01-1.09; BMI 1.10/kg/m2, 1.01-1.19; Overweight 2.22/yes, 1.21-4.08; fat mass 1.11/kg, 1.01-1.22), but not tibiofemoral cartilage defects. Childhood adiposity measures were not significantly associated with adulthood knee BMLs except for the association between childhood overweight status and adulthood patellar BMLs (RR 2.87/yes, 95% CI 1.10-7.53). These significant associations persisted after adjustment for corresponding adulthood adiposity measure.

Conclusion: Childhood adiposity measures were associated with the increased risk of adulthood patellar cartilage defects and, to a lesser extent, BMLs, independent of adulthood adiposity measures. These results suggest that adiposity in childhood has long-term effects on patellar structural abnormalities in young adults.

Item Details

Item Type:Refereed Article
Keywords:childhood, adiposity, cartilage defects, bone marrow lesions
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Rheumatology and Arthritis
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
UTAS Author:Meng, T (Mr Tao Meng)
UTAS Author:Venn, A (Professor Alison Venn)
UTAS Author:Wu, F (Dr Feitong Wu)
UTAS Author:Dwyer, T (Professor Terry Dwyer)
UTAS Author:Laslett, LL (Dr Laura Laslett)
UTAS Author:Jones, G (Professor Graeme Jones)
UTAS Author:Ding, C (Professor Chang-Hai Ding)
UTAS Author:Antony, B (Dr Benny Eathakkattu Antony)
ID Code:126361
Year Published:2018
Funding Support:National Health and Medical Research Council (1070586)
Deposited By:Menzies Institute for Medical Research
Deposited On:2018-06-06
Last Modified:2019-11-18
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