126273 - The cascading pathogenic consequences of Sarcoptes scabiei infection that manifest in host disease.pdf (1.68 MB)
The cascading pathogenic consequences of Sarcoptes scabiei infection that manifest in host disease
journal contribution
posted on 2023-05-19, 18:31 authored by Martin, AM, Fraser, TA, Lesku, JA, Simpson, K, Roberts, GL, Garvey, J, Polkinghorne, A, Christopher BurridgeChristopher Burridge, Scott CarverScott CarverSarcoptic mange, caused by the parasitic mite Sarcoptes scabiei, causes a substantive burden of disease to humans, domestic animals and wildlife, globally. There are many effects of S. scabiei infection, culminating in the disease which hosts suffer. However, major knowledge gaps remain on the pathogenic impacts of this infection. Here, we focus on the bare-nosed wombat host (Vombatus ursinus) to investigate the effects of mange on: (i) host heat loss and thermoregulation, (ii) field metabolic rates, (iii) foraging and resting behaviour across full circadian cycles, and (iv) fatty acid composition in host adipose, bone marrow, brain and muscle tissues. Our findings indicate that mange-infected V. ursinus lose more heat to the environment from alopeciaaffected body regions than healthy individuals. Additionally, mange-infected individuals have higher metabolic rates in the wild. However, these metabolic demands are difficult to meet, because infected individuals spend less time foraging and more time inactive relative to their healthy counterparts, despite being outside of the burrow for longer.
History
Publication title
Royal Society Open ScienceVolume
5Issue
4Article number
180018Number
180018Pagination
1-14ISSN
2054-5703Department/School
School of Natural SciencesPublisher
The Royal Society PublishingPlace of publication
United KingdomRights statement
© 2018 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/Repository Status
- Open