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Evolved dependence in response to cancer
journal contribution
posted on 2023-05-19, 18:11 authored by Thomas, F, Kareva, I, Raven, N, Rodrigo Hamede RossRodrigo Hamede Ross, Pujol, P, Roche, B, Ujvari, BEvolved dependence is a process through which one species becomes ‘dependent’ on another following a long evolutionary history of interaction. This happens when adaptations selected in the first species for interacting lead to fitness costs when the second species is not encountered. Evolved dependence is frequent in host–parasite interactions, where hosts may achieve a higher fitness in the presence of the parasite than in its absence. Since oncogenic manifestations are (i) ubiquitous across multicellular life, (ii) involved in parasitic-like interactions with their hosts, and (iii) have effectively driven the selection of numerous adaptations, it is possible that multicellular organisms display evolved dependence in response to oncogenic processes. We provide a comprehensive overview of the topic, including the implications for cancer prevention and treatment.
History
Publication title
Trends in Ecology and EvolutionVolume
33Issue
4Pagination
269-276ISSN
0169-5347Department/School
School of Natural SciencesPublisher
Elsevier Science LondonPlace of publication
84 Theobalds Rd, London, England, Wc1X 8RrRights statement
Copyright 2018 Elsevier Ltd.Repository Status
- Restricted