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Principles around accurate blood volume collection using capillary action
journal contribution
posted on 2023-05-19, 18:07 authored by Lapierre, F, Gooley, A, Michael BreadmoreMichael BreadmoreCapillary action is one mechanism microfluidics uses to draw liquid autonomously in a substrate without the need of external energy. This behavior can be exploited to collect accurate volumes of liquids such as blood in narrow columns known as capillary tubes and help the development of inexpensive, user-friendly personalized biomedical tools. Precision bore glass capillaries demonstrate the “state of the art” for volume accuracy and precision, but height and radius must be carefully chosen in order to exploit the capillary action behavior efficiently. This Article investigates the influence of surface glass aging, due to prolonged exposure to humid air, and hematocrit level on the blood capillary rise. It provides also the tools to correctly define the optimum capillary dimensions to collect an accurate volume of blood in a glass capillary tube.
History
Publication title
LangmuirVolume
33Issue
50Pagination
14220-14225ISSN
0743-7463Department/School
School of Natural SciencesPublisher
American Chemical SocietyPlace of publication
1155 16Th St, Nw, Washington, USA, Dc, 20036Rights statement
Copyright 2017 American Chemical SocietyRepository Status
- Restricted