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Maternal smoking during pregnancy and offspring overweight: is there a dose-response relationship? An individual patient data meta-analysis

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Albers, L and Sobotzki, C and Kuss, O and Ajslev, T and Batista, RFL and Bettiol, H and Brabin, B and Buka, SL and Cardoso, VC and Clifton, VL and Devereux, G and Gilman, SE and Grzeskowiak, LE and Heinrich, J and Hummel, S and Jacobsen, GW and Jones, G and Koshy, G and Morgen, CS and Oken, E and Paus, T and Pausova, Z and Rifas-Shiman, SL and Sharma, AJ and da Silva, AAM and Sorensen, TIA and Thiering, E and Turner, S and Vik, T and von Kries, R, Maternal smoking during pregnancy and offspring overweight: is there a dose-response relationship? An individual patient data meta-analysis, International Journal of Obesity pp. 1-16. ISSN 0307-0565 (2018) [Refereed Article]


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DOI: doi:10.1038/s41366-018-0050-0

Abstract

Background/Objectives: A number of meta-analyses suggest an association between any maternal smoking in pregnancy and offspring overweight obesity. Whether there is a dose-response relationship across number of cigarettes and whether this differs by sex remains unclear.

Subject/Methods: Studies reporting number of cigarettes smoked during pregnancy and offspring BMI published up to May 2015 were searched. An individual patient data meta-analysis of association between the number of cigarettes smoked during pregnancy and offspring overweight (defined according to the International Obesity Task Force reference) was computed using a generalized additive mixed model with non-linear effects and adjustment for confounders (maternal weight status, breastfeeding, and maternal education) and stratification for sex.

Results: Of 26 identified studies, 16 authors provided data on a total of 238,340 mother-child-pairs. A linear positive association was observed between the number of cigarettes smoked and offspring overweight for up to 15 cigarettes per day with an OR increase per cigarette of 1.03, 95% CI = [1.02-1.03]. The OR flattened with higher cigarette use. Associations were similar in males and females. Sensitivity analyses supported these results.

Conclusions: A linear dose-response relationship of maternal smoking was observed in the range of 1-15 cigarettes per day equally in boys and girls with no further risk increase for doses above 15 cigarettes.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Rheumatology and Arthritis
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
Author:Jones, G (Professor Graeme Jones)
ID Code:125947
Year Published:2018
Deposited By:Menzies Institute for Medical Research
Deposited On:2018-05-16
Last Modified:2018-05-16
Downloads:0

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