Albers, L and Sobotzki, C and Kuss, O and Ajslev, T and Batista, RFL and Bettiol, H and Brabin, B and Buka, SL and Cardoso, VC and Clifton, VL and Devereux, G and Gilman, SE and Grzeskowiak, LE and Heinrich, J and Hummel, S and Jacobsen, GW and Jones, G and Koshy, G and Morgen, CS and Oken, E and Paus, T and Pausova, Z and Rifas-Shiman, SL and Sharma, AJ and da Silva, AAM and Sorensen, TIA and Thiering, E and Turner, S and Vik, T and von Kries, R, Maternal smoking during pregnancy and offspring overweight: is there a dose-response relationship? An individual patient data meta-analysis, International Journal of Obesity pp. 1-16. ISSN 0307-0565 (2018) [Refereed Article]
Copyright 2018 Macmillan Publishers Limited, part of Springer Nature
Subject/Methods: Studies reporting number of cigarettes smoked during pregnancy and offspring BMI published up to May 2015 were searched. An individual patient data meta-analysis of association between the number of cigarettes smoked during pregnancy and offspring overweight (defined according to the International Obesity Task Force reference) was computed using a generalized additive mixed model with non-linear effects and adjustment for confounders (maternal weight status, breastfeeding, and maternal education) and stratification for sex.
Results: Of 26 identified studies, 16 authors provided data on a total of 238,340 mother-child-pairs. A linear positive association was observed between the number of cigarettes smoked and offspring overweight for up to 15 cigarettes per day with an OR increase per cigarette of 1.03, 95% CI = [1.02-1.03]. The OR flattened with higher cigarette use. Associations were similar in males and females. Sensitivity analyses supported these results.
Conclusions: A linear dose-response relationship of maternal smoking was observed in the range of 1-15 cigarettes per day equally in boys and girls with no further risk increase for doses above 15 cigarettes.
|Item Type:||Refereed Article|
|Research Division:||Medical and Health Sciences|
|Research Group:||Clinical Sciences|
|Research Field:||Rheumatology and Arthritis|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Skeletal System and Disorders (incl. Arthritis)|
|Author:||Jones, G (Professor Graeme Jones)|
|Deposited By:||Menzies Institute for Medical Research|
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