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Maternal smoking during pregnancy and offspring overweight: is there a dose-response relationship? An individual patient data meta-analysis
Citation
Albers, L and Sobotzki, C and Kuss, O and Ajslev, T and Batista, RFL and Bettiol, H and Brabin, B and Buka, SL and Cardoso, VC and Clifton, VL and Devereux, G and Gilman, SE and Grzeskowiak, LE and Heinrich, J and Hummel, S and Jacobsen, GW and Jones, G and Koshy, G and Morgen, CS and Oken, E and Paus, T and Pausova, Z and Rifas-Shiman, SL and Sharma, AJ and da Silva, AA and Sorensen, TI and Thiering, E and Turner, S and Vik, T and von Kries, R, Maternal smoking during pregnancy and offspring overweight: is there a dose-response relationship? An individual patient data meta-analysis, International Journal of Obesity, 42, (7) pp. 1249-1264. ISSN 0307-0565 (2018) [Refereed Article]
Copyright Statement
Copyright 2018 Macmillan Publishers Limited, part of Springer Nature
DOI: doi:10.1038/s41366-018-0050-0
Abstract
Subject/Methods: Studies reporting number of cigarettes smoked during pregnancy and offspring BMI published up to May 2015 were searched. An individual patient data meta-analysis of association between the number of cigarettes smoked during pregnancy and offspring overweight (defined according to the International Obesity Task Force reference) was computed using a generalized additive mixed model with non-linear effects and adjustment for confounders (maternal weight status, breastfeeding, and maternal education) and stratification for sex.
Results: Of 26 identified studies, 16 authors provided data on a total of 238,340 mother-child-pairs. A linear positive association was observed between the number of cigarettes smoked and offspring overweight for up to 15 cigarettes per day with an OR increase per cigarette of 1.03, 95% CI = [1.02-1.03]. The OR flattened with higher cigarette use. Associations were similar in males and females. Sensitivity analyses supported these results.
Conclusions: A linear dose-response relationship of maternal smoking was observed in the range of 1-15 cigarettes per day equally in boys and girls with no further risk increase for doses above 15 cigarettes.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Paediatrics |
| Research Field: | Paediatrics not elsewhere classified |
| Objective Division: | Health |
| Objective Group: | Public health (excl. specific population health) |
| Objective Field: | Behaviour and health |
| UTAS Author: | Jones, G (Professor Graeme Jones) |
| ID Code: | 125947 |
| Year Published: | 2018 |
| Web of Science® Times Cited: | 29 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2018-05-16 |
| Last Modified: | 2022-08-25 |
| Downloads: | 0 |
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