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The importance of synovial inflammation in osteoarthritis: current evidence from imaging assessments and clinical trials

journal contribution
posted on 2023-05-19, 17:46 authored by Wang, X, Hunter, DJ, Jin, X, Chang-Hai DingChang-Hai Ding
Synovial abnormalities have been observed at multiple stages of osteoarthritis (OA). Increasing evidence suggests that it may play an important role in the OA pathological process. Many assessment systems using magnetic resonance imaging (MRI) and ultrasound have been established to detect synovial inflammation in OA. These have been used to inform the current investigation of OA disease phenotypes and progression and can be utilised in the future for clinical trials developing potential treatments. This narrative review aims to illustrate the importance of synovial tissue in OA and provide an overview of imaging assessments and possible therapies targeting synovial abnormalities.

History

Publication title

Osteoarthritis and Cartilage

Volume

26

Pagination

165-174

ISSN

1063-4584

Department/School

Menzies Institute for Medical Research

Publisher

W B Saunders Co Ltd

Place of publication

32 Jamestown Rd, London, England, Nw1 7By

Rights statement

© 2017 Osteoarthritis Research Society International. Published by Elsevier Ltd.

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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