eCite Digital Repository

Genomic effects of the vitamin D receptor: Potentially the link between vitamin D, immune cells, and multiple sclerosis


Lu, M and Taylor, BV and Korner, H, Genomic effects of the vitamin D receptor: Potentially the link between vitamin D, immune cells, and multiple sclerosis, Frontiers in Immunology, 9 Article 477. ISSN 1664-3224 (2018) [Refereed Article]


Copyright Statement

2018 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0)

DOI: doi:10.3389/fimmu.2018.00477


Vitamin D has a plethora of functions that are important for the maintenance of general health and in particular, the functional integrity of the immune system, such as promoting an anti-inflammatory cytokine profile and reducing the Treg/Th17 ratio. Multiple sclerosis (MS) is a chronic, inflammatory, and neurodegenerative central nervous system (CNS) disorder of probable autoimmune origin. MS is characterized by recurring or progressive demyelination and degeneration of the CNS due in part to a misguided immune response to as yet undefined (CNS) antigens, potentially including myelin basic protein and proteolipid protein. MS has also been shown to be associated significantly with environmental factors such as the lack of vitamin D. The role of vitamin D in the pathogenesis and progression of MS is complex. Recent genetic studies have shown that various common MS-associated risk-single-nucleotide polymorphisms (SNPs) are located within or in the vicinity of genes associated with the complex metabolism of vitamin D. The functional aspects of these genetic associations may be explained either by a direct SNP-associated loss- or gain-of-function in a vitamin D-associated gene or due to a change in the regulation of gene expression in certain immune cell types. The development of new genetic tools using next-generation sequencing: e.g., chromatin immunoprecipitation sequencing (ChIP-seq) and the accompanying rapid progress of epigenomics has made it possible to recognize that the association between vitamin D and MS could be based on the extensive and characteristic genomic binding of the vitamin D receptor (VDR). Therefore, it is important to analyze comprehensively the spatiotemporal VDR binding patterns that have been identified using ChIP-seq in multiple immune cell types to reveal an integral profile of genomic VDR interaction. In summary, the aim of this review is to connect genomic effects vitamin D has on immune cells with MS and thus, to contribute to a better understanding of the influence of vitamin D on the etiology and the pathogenesis of this complex autoimmune disease.

Item Details

Item Type:Refereed Article
Keywords:environment, genetics, immune system, multiple sclerosis, vitamin D
Research Division:Biomedical and Clinical Sciences
Research Group:Immunology
Research Field:Immunology not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Lu, M (Dr Ming Lu)
UTAS Author:Taylor, BV (Professor Bruce Taylor)
UTAS Author:Korner, H (Professor Heinrich Korner)
ID Code:125649
Year Published:2018
Web of Science® Times Cited:35
Deposited By:Menzies Institute for Medical Research
Deposited On:2018-04-26
Last Modified:2022-08-25
Downloads:87 View Download Statistics

Repository Staff Only: item control page