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Individualized fracture risk feedback and long-term benefits after 10 years


Wu, F and Wills, K and Laslett, LL and Riley, MD and Oldenburg, B and Jones, G and Winzenberg, T, Individualized fracture risk feedback and long-term benefits after 10 years, American Journal of Preventive Medicine, 54, (2) pp. 266-274. ISSN 0749-3797 (2018) [Refereed Article]


Copyright Statement

Copyright 2017 American Journal of Preventive Medicine. Manuscript version is licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)

DOI: doi:10.1016/j.amepre.2017.10.018


Introduction: This study aimed to determine if beneficial effects of individualized feedback of fracture risk on osteoporosis preventive behaviors and bone mineral density observed in a 2-year trial were sustained long-term.

Methods: This was a 10-year follow-up of a 2-year RCT in 470 premenopausal women aged 25-44 years, who were randomized to one of two educational interventions (the Osteoporosis Prevention and Self-Management Course [OPSMC] or an osteoporosis information leaflet) and received tailored feedback of their relative risk of fracture in later life (high versus normal risk groups). Bone mineral density of lumbar spine and femoral neck were measured by dual-energy X-ray absorptiometry. Physical activity, dietary calcium intake, calcium and vitamin D supplements, and smoking status were measured by questionnaires.

Results: From 2 to 12 years, the high-risk group had a smaller decrease in femoral neck bone mineral density (β=0.023, 95% CI=0.005, 0.041 g/cm2) but similar lumbar spine bone mineral density change as the normal-risk group. They were more likely to use calcium (relative risk=1.66, 95% CI=1.22, 2.24) and vitamin D supplements (1.99, 95% CI=1.27, 3.11). The OPSMC had no effects on bone mineral density change. Both high-risk (versus normal-risk) and the OPSMC groups (versus leaflet) had a more favorable pattern of smoking behavior change (relative risk=1.85, 95% CI=0.70, 4.89 and relative risk=2.27, 95% CI=0.86, 6.01 for smoking cessation; relative risk=0.33, 95% CI=0.13, 0.80 and relative risk=0.28, 95% CI=0.10, 0.79 for commenced or persistent smoking).

Conclusions: Feedback of high fracture risk to younger women was associated with long-term improvements in osteoporosis preventive behaviors and attenuated femoral neck bone mineral density loss. Therefore, this could be considered as a strategy to prevent osteoporosis.

Item Details

Item Type:Refereed Article
Keywords:fracture risk, osteoporosis, bone mineral density, preventive behaviours
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Rheumatology and arthritis
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Wu, F (Dr Feitong Wu)
UTAS Author:Wills, K (Dr Karen Wills)
UTAS Author:Laslett, LL (Dr Laura Laslett)
UTAS Author:Jones, G (Professor Graeme Jones)
UTAS Author:Winzenberg, T (Professor Tania Winzenberg)
ID Code:125647
Year Published:2018
Web of Science® Times Cited:2
Deposited By:Menzies Institute for Medical Research
Deposited On:2018-04-26
Last Modified:2019-12-05
Downloads:6 View Download Statistics

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