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Childhood cardiorespiratory fitness, muscular fitness and adult measures of glucose homeostasis

Citation

Fraser, BJ and Blizzard, L and Schmidt, MD and Juonala, M and Dwyer, T and Venn, AJ and Magnussen, CG, Childhood cardiorespiratory fitness, muscular fitness and adult measures of glucose homeostasis, Journal of Science and Medicine in Sport pp. 1-6. ISSN 1440-2440 (2018) [Refereed Article]

Copyright Statement

Copyright 2018 Sports Medicine Australia

DOI: doi:10.1016/j.jsams.2018.02.002

Abstract

Objectives: To assess whether childhood cardiorespiratory fitness (CRF) and muscular fitness phenotypes (strength, power, endurance) predict adult glucose homeostasis measures.

Design: Prospective longitudinal study.

Methods: Study examining participants who had physical fitness measured in childhood (aged 7-15 years) and who attended follow-up clinics approximately 20 years later and provided a fasting blood sample which was tested for glucose and insulin. Physical fitness measurements included muscular strength (right and left grip, shoulder flexion, shoulder and leg extension), power (standing long jump distance) and endurance (number of push-ups in 30s), and CRF (1.6km run duration). In adulthood, fasting glucose and insulin levels were used to derive glucose homeostasis measures of insulin resistance (HOMA2-IR) and beta cell function (HOMA2-β).

Results: A standard deviation increase in childhood CRF or muscular strength (males) was associated with fasting glucose (CRF: β=-0.06mmol/L), fasting insulin (CRF: β=-0.73mU/L; strength: β=-0.40mU/L), HOMA2-IR (CRF: β=-0.06; strength: β=-0.05) and HOMA2-β (CRF: β=-3.06%; strength: β=-2.62%) in adulthood, independent of the alternative fitness phenotype (all p<0.01). Adjustment for childhood waist circumference reduced the effect by 17-35% for CRF and 0-15% for muscular strength (males) and statistical significance remained for all associations expect between CRF, fasting glucose and HOMA2-β (p>0.06).

Conclusions: CRF and muscular fitness in childhood were inversely associated with measures of fasting insulin, insulin resistance and beta cell function in adulthood. Childhood CRF and muscular fitness could both be potential independent targets for strategies to help reduce the development of adverse glucose homeostasis.

Item Details

Item Type:Refereed Article
Keywords:beta cell function, cohort, epidemiology, insulin resistance, muscle strength, physical fitness
Research Division:Medical and Health Sciences
Research Group:Public Health and Health Services
Research Field:Epidemiology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cardiovascular System and Diseases
Author:Fraser, BJ (Mrs Brooklyn Fraser)
Author:Blizzard, L (Professor Leigh Blizzard)
Author:Dwyer, T (Professor Terry Dwyer)
Author:Venn, AJ (Professor Alison Venn)
Author:Magnussen, CG (Dr Costan Magnussen)
ID Code:125640
Year Published:2018
Deposited By:Menzies Institute for Medical Research
Deposited On:2018-04-26
Last Modified:2018-05-02
Downloads:0

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