Wu, F and Juonala, M and Pitkanen, N and Jula, A and Lehtimaki, T and Sabin, MA and Pahkala, K and Hutri-Kahonen, N and Kahonen, M and Laitinen, T and Viikari, JSA and Magnussen, CG and Raitakari, OT, Both youth and long-term vitamin D status is associated with risk of type 2 diabetes mellitus in adulthood: a cohort study, Annals of Medicine, 50, (1) pp. 74-82. ISSN 0785-3890 (2018) [Refereed Article]
Copyright 2017 Informa UK Limited
Materials and Methods: This was a 31-year follow-up study of 2300 participants aged 3-18 years. Multinomial logistic regression was used to assess the association of both (a) baseline 25-hydroxyvitamin D (25OHD) levels and (b) the mean of baseline and the latest follow-up 25OHD levels (continuous variable and quartiles) with incident T2DM and IFG (cut-off = 5.6 mmol/L) in adult life.
Results: High serum 25OHD levels in youth and also mean values from youth to adulthood were associated with reduced risk of developing T2DM in adulthood (odds ratio, 95% confidence interval= 0.73, 0.57-0.95 and 0.65, 0.51-0.84, respectively, for each SD increment in 25OHD). Compared to Q1, a dose-dependent negative association was observed across other quartiles of youth 25OHD, while the strongest association was found in the Q3 for the mean 25OHD levels. Neither youth nor the mean 25OHD was associated with IFG.Conclusions: High serum 25OHD levels in youth, and from child to adult life, were associated with a reduced risk of developing T2DM in adulthood.
|Item Type:||Refereed Article|
|Keywords:||25-hydroxyvitamin D, impaired fasting glucose, type 2 diabetes mellitus, youth|
|Research Division:||Medical and Health Sciences|
|Research Group:||Public Health and Health Services|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Cardiovascular System and Diseases|
|UTAS Author:||Wu, F (Dr Feitong Wu)|
|UTAS Author:||Magnussen, CG (Dr Costan Magnussen)|
|Web of Science® Times Cited:||8|
|Deposited By:||Menzies Institute for Medical Research|
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