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Composite ganglioside autoantibodies and immune treatment response in MMN and MADSAM

Citation

Martinez-Thompson, JM and Snyder, MR and Ettore, M and McKeon, A and Pittock, SJ and Roforth, MM and Mandrekar, J and Mauermann, ML and Taylor, BV and Dyck, PJB and Windebank, AJ and Klein, CJ, Composite ganglioside autoantibodies and immune treatment response in MMN and MADSAM, Muscle and Nerve, 57, (6) pp. 1000-1005. ISSN 0148-639X (2018) [Refereed Article]

Copyright Statement

Copyright 2017 Wiley Periodicals, Inc.

DOI: doi:10.1002/mus.26051

Abstract

Introduction: Multifocal motor neuropathy (MMN) is a motor only, asymmetric onset neuropathy that is relatively treatment-refractory compared with classic chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and multifocal acquired demyelinating sensory and motor (MADSAM) neuropathy.

Methods: We reviewed 35 patients seropositive for GM1 (monosialo-asialo [immunoglobulin M, IgM; immunoglobulin G, IgG]) and/or GD1b (disialo [IgG, IgM]) autoantibodies having MMN, classic CIDP, or MADSAM. Immune-treatment responsiveness and clinical course was compared with antibody negative disease controls.

Results: Seventy-nine percent of seropositives with an initial diagnosis of MMN were immunotherapy responsive compared with 46% of seronegatives (P = 0.045). Eight ganglioside antibody positive MMN patients of 19 (42%) developed sensory findings consistent with MADSAM compared with 3 of 41 (7%) seronegative MMN patients (P = 0.003). MMN and MADSAM patients with ganglioside antibody positivity had more sustained treatment responses (P = 0.03).

Discussion: Patients initially diagnosed with MMN seropositive for diverse GM1 autoantibodies appear more likely to have sustained treatment response and evolution to MADSAM.

Item Details

Item Type:Refereed Article
Keywords:CIDP, MADSAM, MMN, gangliosides
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Central Nervous System
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:Taylor, BV (Professor Bruce Taylor)
ID Code:125489
Year Published:2018
Deposited By:Menzies Institute for Medical Research
Deposited On:2018-04-19
Last Modified:2018-05-15
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