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Variations in subclinical left ventricular dysfunction, functional capacity, and clinical outcomes in different heart failure aetiologies
Citation
Wang, Y and Yang, H and Nolan, M and Pathan, F and Negishi, K and Marwick, TH, Variations in subclinical left ventricular dysfunction, functional capacity, and clinical outcomes in different heart failure aetiologies, ESC Heart Failure, 5, (3) pp. 343-354. ISSN 2055-5822 (2018) [Refereed Article]
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Copyright Statement
Copyright 2018 The Authors. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) https://creativecommons.org/licenses/by-nc-nd/4.0/
Abstract
Methods and Results: We recruited 551 elder asymptomatic SAHF patients (age 71 ± 5 years, 49% men, 290 T2DM) with at least one risk factor from a community-based population with preserved ejection fraction. All underwent a comprehensive echocardiogram including global longitudinal strain (GLS) and a 6 min walk test and were followed for 2 years. The primary endpoints were new-onset HF and all-cause mortality. The T2DM group was associated with reduced 6 min walk test distance (451 ± 111 vs. 493 ± 87 m, P < 0.001), worse diastolic function (E/e' 9.2 ± 2.7 vs. 8.7 ± 2.4, P = 0.028), and impaired GLS (-17.7 ± 2.6% vs. -19.0 ± 2.6%, P < 0.001). Over a median follow-up of 1.6 years, 49 T2DM-SAHF and 27 other-SAHF met the primary endpoint. T2DM-SAHF had significantly worse outcome than other-SAHF (P = 0.021). In Cox models, obesity [hazard ratio (HR) = 2.46; P = 0.007], atrial fibrillation (HR = 2.39; P = 0.028), 6 min walk distance (HR = 0.99; P = 0.034), and GLS (HR = 1.14; P = 0.033) were independently associated with the primary endpoint in T2DM-SAHF, independent of age and glycaemic control.
Conclusions: The T2DM-SAHF has worse subclinical left ventricular function, exercise capacity, and prognosis than other-SAHF. Impaired GLS, atrial fibrillation, exercise capacity, and obesity are associated with a worse prognosis in T2DM-SAHF but not in other-SAHF.
Item Details
Item Type: | Refereed Article |
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Keywords: | 6 min walk, diabetes mellitus, global longitudinal strain, heart failure |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Cardiovascular medicine and haematology |
Research Field: | Cardiology (incl. cardiovascular diseases) |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Wang, Y (Ms Ying Wang) |
UTAS Author: | Yang, H (Ms Hilda Yang) |
UTAS Author: | Nolan, M (Mr Mark Nolan) |
UTAS Author: | Pathan, F (Dr Faraz Pathan) |
UTAS Author: | Negishi, K (Dr Kazuaki Negishi) |
UTAS Author: | Marwick, TH (Professor Tom Marwick) |
ID Code: | 125466 |
Year Published: | 2018 |
Web of Science® Times Cited: | 8 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2018-04-18 |
Last Modified: | 2022-08-25 |
Downloads: | 95 View Download Statistics |
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