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Successful treatment of concomitant metastatic prostate cancer and B-cell non-Hodgkin’s lymphoma with R-EPOCH chemotherapy regimen and antiandrogen therapy
Citation
Hanna, F and Prakash, A and Allan, E and Khalafallah, AA, Successful treatment of concomitant metastatic prostate cancer and B-cell non-Hodgkin's lymphoma with R-EPOCH chemotherapy regimen and antiandrogen therapy, BMJ Case Reports pp. 1-6. ISSN 1757-790X (2017) [Contribution to Refereed Journal]
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DOI: doi:10.1136/bcr-2017- 223637
Abstract
A 70-year-old man presented with left loin pain without
urinary symptoms. Initial investigations with CT showed
enlarged para-aortic, mediastinal lymph nodes, rightside
renal mass and enlarged prostate. A prostaticspecific
antigen (PSA) was alarmingly high at 4750 μg/L
(normal <4.0 μg/L). Further investigations included
positron emission tomography (PET); both prostatespecific
membrane antigen and 18-fluorodeoxyglucose
as well as bone scan and bone marrow examination
confirmed dual malignancies with B-cell non-Hodgkin’s
lymphoma (B-NHL) and wide spread metastatic
prostatic adenocarcinoma (PA ) to the skull, spine,
pelvis, liver and lungs. The patient was treated with six
cycles of rituximab, etoposide, prednisone, vincristine,
cyclophosphamide and doxorubicin(R-EPOCH) containing
regimen for B-NHL and goserelin hormonal therapy
for PA . Restaging with PET scans thereafter showed
complete remission of NHL with disappearance of his
metastatic PA and normalisation of PSA levels. R-EPOCH
regimen and antiandrogen therapy resulted in a good
outcome and remission of both malignancies.
Item Details
Item Type: | Contribution to Refereed Journal |
---|---|
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Cardiovascular medicine and haematology |
Research Field: | Haematology |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Diagnosis of human diseases and conditions |
UTAS Author: | Hanna, F (Dr Fayez Hanna) |
UTAS Author: | Khalafallah, AA (Professor Alhossain Khalafallah) |
ID Code: | 125432 |
Year Published: | 2017 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2018-04-17 |
Last Modified: | 2018-04-17 |
Downloads: | 0 |
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