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High resolution propagation-based imaging system for in vivo dynamic computed tomography of lungs in small animals

Citation

Preissner, M and Murrie, RP and Pinar, I and Werdiger, F and Carnibella, RP and Zosky, GR and Dubsky, S, High resolution propagation-based imaging system for in vivo dynamic computed tomography of lungs in small animals, Physics in medicine and biology, 63, (8) pp. 1-8. ISSN 0031-9155 (2018) [Refereed Article]


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Copyright Statement

2018 Institute of Physics and Engineering in Medicine. Licensed under Creative Commons Attribution 3.0 Unported (CC BY 3.0) https://creativecommons.org/licenses/by/3.0/

DOI: doi:10.1088/1361-6560/aab8d2

Abstract

We have developed an x-ray imaging system for I>in vivo four-dimensional computed tomography (4DCT) of small animals for pre-clinical lung investigations. Our customized laboratory facility is capable of high resolution in vivo imaging at high frame rates. Characterization using phantoms demonstrate a spatial resolution of slightly below 50 μm at imaging rates of 30 Hz, and the ability to quantify material density differences of at least 3%. We benchmark our system against existing small animal pre-clinical CT scanners using a quality factor that combines spatial resolution, image noise, dose and scan time. In vivo. 4DCT images obtained on our system demonstrate resolution of important features such as blood vessels and small airways, of which the smallest discernible were measured as 5560 μm in cross section. Quantitative analysis of the images demonstrate regional differences in ventilation between injured and healthy lungs.

Item Details

Item Type:Refereed Article
Keywords:4DCT, in vivo, x-ray imaging, functional imaging, biological imaging, tomography
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Respiratory Diseases
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Respiratory System and Diseases (incl. Asthma)
Author:Zosky, GR (Associate Professor Graeme Zosky)
ID Code:125430
Year Published:2018
Funding Support:National Health and Medical Research Council (1077905)
Deposited By:Medicine (Discipline)
Deposited On:2018-04-17
Last Modified:2018-06-04
Downloads:6 View Download Statistics

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