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Adherence to oral anticoagulants in atrial fibrillation: an Australian survey


Obamiro, KO and Chalmers, L and Lee, K and Bereznicki, BJ and Bereznicki, LR, Adherence to oral anticoagulants in atrial fibrillation: an Australian survey, Journal of Cardiovascular Pharmacology and Therapeutics, 23, (4) pp. 337-343. ISSN 1074-2484 (2018) [Refereed Article]

Copyright Statement

Copyright The Author(s) 2018

DOI: doi:10.1177/1074248418770201


Background: The aim of this study was to investigate the proportion of patients who have suboptimal adherence to oral anticoagulant (OAC), identify the predictors of adherence, and determine whether patient-related factors vary across adherence levels in Australia.

Methods: Respondents were recruited for an online survey using Facebook. Survey instruments included the Morisky Medication Adherence Scale, the Anticoagulation Knowledge Tool, the Perception of Anticoagulant Treatment Questionnaires, and a modified Cancer Information Overload scale. Predictors of medication adherence were identified using ordinal regression analysis.

Results: Of the 386 responses eligible for analysis, only 54.9% reported a high level of adherence. Participants aged 65 years or younger were less likely to have high adherence compared to older participants (odds ratio [OR], 0.54; 95% confidence interval [CI], 0.33-0.88; P = .013), while females were more likely to be highly adherent compared to males (OR, 1.69; 95% CI, 1.08-2.64; P = .023). The analyses showed that age, gender, treatment satisfaction, information overload, concerns about making mistake when taking OACs, and cost of medication were significant predictors of adherence.

Conclusion: Self-reported suboptimal adherence to OAC is common among patients with atrial fibrillation. A focus on supporting people who are at higher risk of suboptimal adherence is needed to maximize the benefit of OAC therapy in this population.

Item Details

Item Type:Refereed Article
Keywords:adherence, oral anticoagulant, atrial fibrillation
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Clinical pharmacy and pharmacy practice
Objective Division:Health
Objective Group:Other health
Objective Field:Other health not elsewhere classified
UTAS Author:Obamiro, KO (Dr Kehinde Obamiro)
UTAS Author:Chalmers, L (Dr Leanne Chalmers)
UTAS Author:Lee, K (Dr Kenneth Lee)
UTAS Author:Bereznicki, BJ (Dr Bonnie Bereznicki)
UTAS Author:Bereznicki, LR (Professor Luke Bereznicki)
ID Code:125408
Year Published:2018
Web of Science® Times Cited:18
Deposited By:Pharmacy
Deposited On:2018-04-17
Last Modified:2019-03-25

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