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Membrane assisted and temperature controlled on-line evaporative concentration for microfluidics


Fornells, E and Barnett, B and Bailey, M and Shellie, RA and Hilder, EF and Breadmore, MC, Membrane assisted and temperature controlled on-line evaporative concentration for microfluidics, The Journal of Chromatography A, 1486 pp. 110-116. ISSN 0021-9673 (2017) [Refereed Article]

Copyright Statement

© 2016 Elsevier B.V. All rights reserved.

DOI: doi:10.1016/j.chroma.2016.12.003


A membrane evaporation concentrator for continuous flow conditions is introduced. The membrane evaporation concentrator provides nearly 30-fold concentration in less than 60 min whilst maintaining solute integrity under different sub-ambient pressure conditions and mild temperatures. To better understand the performance of the concentrator, a theoretical model was developed using caffeine as a model analyte, and used to predict the concentration performance of three target analytes at different conditions. An exponential relationship exists between temperature and concentration factor. By using the model it was determined that a 10-fold concentration (±0.5) can be performed at 56.72 ± 0.07 °C and at a flow rate of 10 μL min−1. Altogether, the model provides a better understanding of the process and ease of application in a wide variety of analytical methods. This work demonstrates that it is possible to obtain high concentrations with a continuously flowing fluid when temperature is precisely controlled and in times that are reasonable compared to existing evaporation concentration procedures.

Item Details

Item Type:Refereed Article
Research Division:Chemical Sciences
Research Group:Analytical chemistry
Research Field:Separation science
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the chemical sciences
UTAS Author:Fornells, E (Miss Elisenda Fornells Vernet)
UTAS Author:Hilder, EF (Professor Emily Hilder)
UTAS Author:Breadmore, MC (Professor Michael Breadmore)
ID Code:125354
Year Published:2017
Web of Science® Times Cited:6
Deposited By:Austn Centre for Research in Separation Science
Deposited On:2018-04-13
Last Modified:2018-07-27

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