Clifford, S and Mazaheri, M and Salimi, F and Ezz, WN and Yeganeh, B and Low-Choy, S and Walker, K and Mengersen, K and Marks, GB and Morawska, L, Effects of exposure to ambient ultrafine particles on respiratory health and systemic inflammation in children, Environment International, 114 pp. 167-180. ISSN 0160-4120 (2018) [Refereed Article]
Copyright 2018 Elsevier Ltd.
We conducted a cross-sectional study among 655 children (43.3% male) attending 25 primary (elementary) schools in the Brisbane Metropolitan Area, Australia. Ultrafine particle number concentration (PNC) was measured at each school and modelled at homes using Land Use Regression to derive exposure estimates. Health outcomes were respiratory symptoms and diagnoses, measured by parent-completed questionnaire, spirometric lung function, exhaled nitric oxide (FeNO), and serum C reactive protein (CRP). Exposure-response models, adjusted for potential personal and environmental confounders measured at the individual, home and school level, were fitted using Bayesian methods.
PNC was not independently associated with respiratory symptoms, asthma diagnosis or spirometric lung function. However, PNC was positively associated with an increase in CRP (1.188-fold change per 1000 UFP cm-3 day/day (95% credible interval 1.077 to 1.299)) and an increase in FeNO among atopic participants (1.054 fold change per 1000 UFP cm-3 day/day (95% CrI 1.005 to 1.106)).
UFPs do not affect respiratory health outcomes in children but do have systemic effects, detected here in the form of a positive association with a biomarker for systemic inflammation. This is consistent with the known propensity of UFPs to penetrate deep into the lung and circulatory system.
|Item Type:||Refereed Article|
|Keywords:||exposure, respiratory health, schoolchildren, systematic inflammation, ultrafine particles|
|Research Division:||Environmental Sciences|
|Research Group:||Pollution and contamination|
|Research Field:||Pollution and contamination not elsewhere classified|
|Objective Group:||Public health (excl. specific population health)|
|Objective Field:||Public health (excl. specific population health) not elsewhere classified|
|UTAS Author:||Salimi, F (Dr Farhad Salimi)|
|Web of Science® Times Cited:||41|
|Deposited By:||Menzies Institute for Medical Research|
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