Chung, O and Juonala, M and Mallat, Z and Hutri-Kahonen, N and Viikari, JSA and Raitakari, OT and Magnussen, CG, Tracking of secretory phospholipase A2 enzyme activity levels from childhood to adulthood: a 21-year cohort, Jornal de Pediatria pp. 1-8. ISSN 0021-7557 (2018) [Refereed Article]
© 2018 Published by Elsevier Editora Ltda. on behalf of Sociedade Brasileira de Pediatria. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) http://creativecommons.org/licenses/by-nc-nd/4.0/
Method: Prospective cohort of 1735 children (45% females) who had serum sPLA2 enzyme activity levels and other cardiovascular disease risk factors measured in 1980 that were followed-up in 2001.
Results: sPLA2 activity tracked from childhood to adulthood for males (r=0.39) and females (r=0.45). Those who decreased body mass index relative to their peers were more likely to resolve elevated childhood sPLA2 levels than have persistent elevated sPLA2 levels in childhood and adulthood. Those who consumed less fruit, and gained more body mass index relative to their peers, began smoking or were a persistent smoker between childhood and adulthood were more likely to develop incident elevated sPLA2 levels than those with persistent not elevated sPLA2 levels.
Conclusions: Childhood sPLA2 enzyme activity levels associate with adult sPLA2 levels 21 years later. Healthful changes in modifiable risk factors that occur between childhood and adulthood might prevent children from developing elevated sPLA2 levels in adulthood.
|Item Type:||Refereed Article|
|Keywords:||atherosclerosis, cohort study, inflammation, prevention|
|Research Division:||Medical and Health Sciences|
|Research Group:||Public Health and Health Services|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Cardiovascular System and Diseases|
|UTAS Author:||Chung, O (Ms Olivia Chung)|
|UTAS Author:||Magnussen, CG (Dr Costan Magnussen)|
|Deposited By:||Menzies Institute for Medical Research|
|Downloads:||43 View Download Statistics|
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