Munugoda, IP and Wills, K and Cicuttini, F and Graves, SE and Lorimer, M and Jones, G and Callisaya, ML and Aitken, D, The association between ambulatory activity, body composition and hip or knee joint replacement due to osteoarthritis: a prospective cohort study, Osteoarthritis and Cartilage, 26, (5) pp. 671-679. ISSN 1063-4584 (2018) [Refereed Article]
© 2018 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved
Design: At baseline, 1082 community-dwelling older-adults aged 50-80 years were studied. AA was measured objectively using pedometer and body composition by dual-energy X-ray absorptiometry. The incidence of primary (first-time) JR was determined by data linkage to the Australian Orthopaedic Association National Joint Replacement Registry (AOANJRR). Log binomial regression with generalized estimating equations were used to estimate the risk of JR associated with baseline AA and body composition measures, adjusting for age, sex, X-ray disease severity, and pain.
Results: Over 13 years of follow-up, 74 (6.8%) participants had a knee replacement (KR) and 50 (4.7%) a hip replacement (HR). AA was associated with a higher risk of KR (RR 1.09/1000 steps/day, 95% CI 1.01, 1.16) and a lower risk of HR (RR 0.90/1000 steps/day, 95% CI 0.81, 0.99). Body mass index (BMI) (RR 1.07/kg/m2, 95% CI 1.03, 1.12), total fat mass (RR 1.03/kg, 95% CI 1.01, 1.06), trunk fat mass (RR 1.05/kg, 95% CI 1.00, 1.09), and waist circumference (RR 1.02/cm, 95% CI 1.00, 1.04) were associated with a higher risk of KR. Body composition measures were not associated with HR.
Conclusions: An objective measure of AA was associated with a small increased risk of KR and a small reduced risk of HR. Worse body composition profiles were associated with KR, but not HR. Altogether this may suggest different causal pathways for each site with regard to habitual activity and obesity.
|Item Type:||Refereed Article|
|Keywords:||body composition measures, joint replacement, osteoarthritis, physical activity|
|Research Division:||Medical and Health Sciences|
|Research Group:||Clinical Sciences|
|Research Field:||Rheumatology and Arthritis|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Skeletal System and Disorders (incl. Arthritis)|
|UTAS Author:||Munugoda, IP (Mr Ishanka Munugoda)|
|UTAS Author:||Wills, K (Dr Karen Wills)|
|UTAS Author:||Jones, G (Professor Graeme Jones)|
|UTAS Author:||Callisaya, ML (Dr Michele Callisaya)|
|UTAS Author:||Aitken, D (Associate Professor Dawn Aitken)|
|Web of Science® Times Cited:||2|
|Deposited By:||Menzies Institute for Medical Research|
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