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Associations between circulating adipokines and bone mineral density in patients with knee osteoarthritis: a cross-sectional study
Citation
Wu, J and Xu, J and Wang, K and Zhu, Q and Cai, J and Ren, J and Zheng, S and Ding, C, Associations between circulating adipokines and bone mineral density in patients with knee osteoarthritis: a cross-sectional study, BMC Musculoskeletal Disorders, 19, (1) Article 16. ISSN 1471-2474 (2018) [Refereed Article]
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Copyright Statement
Copyright 2018 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
DOI: doi:10.1186/s12891-018-1936-7
Abstract
Methods: This study included 164 patients with symptomatic knee OA from the Anhui Osteoarthritis study. Serum levels of leptin, adiponectin, and resistin were measured using an enzyme-linked immunosorbent assay (ELISA). BMD at total body, spine, hip, and femur were measured by dual-energy X-ray absorptiometry (DXA).
Results: In multivariable analyses, serum levels of leptin were significantly associated with reduced BMD at total body, hip, total femur, femoral neck, and femoral shaft (β = - 0.019, 95% CI -0.034 to - 0.005; β = - 0.018, 95% CI -0.034 to - 0.003; β = - 0.018, 95% CI -0.034 to - 0.002; β = - 0.016, 95% CI -0.032 to 0.000; β = - 0.026, 95% CI -0.046 to - 0.006; respectively). Serum levels of adiponectin were significantly and negatively associated with BMD at total femur and femoral shaft (β = - 0.007, 95% CI -0.013 to 0.000; β = - 0.011, 95% CI -0.018 to - 0.003; respectively). However, no significant associations were found between serum levels of resistin and BMD at any site measured.
Conclusions: Serum levels of leptin and adiponectin were significantly and negatively associated with BMD, suggesting potentially detrimental effects of leptin and adiponectin on BMD in knee OA patients.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | adiponectin, bone mineral density, leptin, osteoarthritis, resistin |
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Clinical sciences |
| Research Field: | Rheumatology and arthritis |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Clinical health not elsewhere classified |
| UTAS Author: | Zheng, S (Miss Shuang Zheng) |
| UTAS Author: | Ding, C (Professor Chang-Hai Ding) |
| ID Code: | 125120 |
| Year Published: | 2018 |
| Web of Science® Times Cited: | 12 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2018-03-28 |
| Last Modified: | 2019-03-05 |
| Downloads: | 64 View Download Statistics |
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