eCite Digital Repository

Associations between circulating adipokines and bone mineral density in patients with knee osteoarthritis: a cross-sectional study

Citation

Wu, J and Xu, J and Wang, K and Zhu, Q and Cai, J and Ren, J and Zheng, S and Ding, C, Associations between circulating adipokines and bone mineral density in patients with knee osteoarthritis: a cross-sectional study, BMC Musculoskeletal Disorders, 19, (1) Article 16. ISSN 1471-2474 (2018) [Refereed Article]


Preview
PDF
602Kb
  

Copyright Statement

Copyright 2018 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

DOI: doi:10.1186/s12891-018-1936-7

Abstract

Background: Associations between adipokines and bone mineral density (BMD) in knee osteoarthritis (OA) remain indistinct. The aim of this study was to investigate the cross-sectional associations between serum levels of adipokines and BMD in patients with knee OA.

Methods: This study included 164 patients with symptomatic knee OA from the Anhui Osteoarthritis study. Serum levels of leptin, adiponectin, and resistin were measured using an enzyme-linked immunosorbent assay (ELISA). BMD at total body, spine, hip, and femur were measured by dual-energy X-ray absorptiometry (DXA).

Results: In multivariable analyses, serum levels of leptin were significantly associated with reduced BMD at total body, hip, total femur, femoral neck, and femoral shaft (β = - 0.019, 95% CI -0.034 to - 0.005; β = - 0.018, 95% CI -0.034 to - 0.003; β = - 0.018, 95% CI -0.034 to - 0.002; β = - 0.016, 95% CI -0.032 to 0.000; β = - 0.026, 95% CI -0.046 to - 0.006; respectively). Serum levels of adiponectin were significantly and negatively associated with BMD at total femur and femoral shaft (β = - 0.007, 95% CI -0.013 to 0.000; β = - 0.011, 95% CI -0.018 to - 0.003; respectively). However, no significant associations were found between serum levels of resistin and BMD at any site measured.

Conclusions: Serum levels of leptin and adiponectin were significantly and negatively associated with BMD, suggesting potentially detrimental effects of leptin and adiponectin on BMD in knee OA patients.

Item Details

Item Type:Refereed Article
Keywords:adiponectin, bone mineral density, leptin, osteoarthritis, resistin
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Rheumatology and arthritis
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Zheng, S (Miss Shuang Zheng)
UTAS Author:Ding, C (Professor Chang-Hai Ding)
ID Code:125120
Year Published:2018
Web of Science® Times Cited:12
Deposited By:Menzies Institute for Medical Research
Deposited On:2018-03-28
Last Modified:2019-03-05
Downloads:64 View Download Statistics

Repository Staff Only: item control page