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Associations between circulating adipokines and bone mineral density in patients with knee osteoarthritis: a cross-sectional study
Citation
Wu, J and Xu, J and Wang, K and Zhu, Q and Cai, J and Ren, J and Zheng, S and Ding, C, Associations between circulating adipokines and bone mineral density in patients with knee osteoarthritis: a cross-sectional study, BMC Musculoskeletal Disorders, 19, (1) Article 16. ISSN 1471-2474 (2018) [Refereed Article]
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Copyright Statement
Copyright 2018 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
DOI: doi:10.1186/s12891-018-1936-7
Abstract
Methods: This study included 164 patients with symptomatic knee OA from the Anhui Osteoarthritis study. Serum levels of leptin, adiponectin, and resistin were measured using an enzyme-linked immunosorbent assay (ELISA). BMD at total body, spine, hip, and femur were measured by dual-energy X-ray absorptiometry (DXA).
Results: In multivariable analyses, serum levels of leptin were significantly associated with reduced BMD at total body, hip, total femur, femoral neck, and femoral shaft (β = - 0.019, 95% CI -0.034 to - 0.005; β = - 0.018, 95% CI -0.034 to - 0.003; β = - 0.018, 95% CI -0.034 to - 0.002; β = - 0.016, 95% CI -0.032 to 0.000; β = - 0.026, 95% CI -0.046 to - 0.006; respectively). Serum levels of adiponectin were significantly and negatively associated with BMD at total femur and femoral shaft (β = - 0.007, 95% CI -0.013 to 0.000; β = - 0.011, 95% CI -0.018 to - 0.003; respectively). However, no significant associations were found between serum levels of resistin and BMD at any site measured.
Conclusions: Serum levels of leptin and adiponectin were significantly and negatively associated with BMD, suggesting potentially detrimental effects of leptin and adiponectin on BMD in knee OA patients.
Item Details
Item Type: | Refereed Article |
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Keywords: | adiponectin, bone mineral density, leptin, osteoarthritis, resistin |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Clinical sciences |
Research Field: | Rheumatology and arthritis |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Zheng, S (Miss Shuang Zheng) |
UTAS Author: | Ding, C (Professor Chang-Hai Ding) |
ID Code: | 125120 |
Year Published: | 2018 |
Web of Science® Times Cited: | 16 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2018-03-28 |
Last Modified: | 2019-03-05 |
Downloads: | 85 View Download Statistics |
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