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Familial resemblance in trabecular and cortical volumetric bone mineral density and bone microarchitecture as measured by HRpQCT


Yang, Y and Pan, F and Wu, F and Squibb, K and Thomson, R and Winzenberg, T and Jones, G, Familial resemblance in trabecular and cortical volumetric bone mineral density and bone microarchitecture as measured by HRpQCT, Bone, 110 pp. 76-83. ISSN 8756-3282 (2018) [Refereed Article]

Copyright Statement

2018 Elsevier Inc. All rights reserved.

DOI: doi:10.1016/j.bone.2018.01.033


To estimate the heritability of bone geometry, volumetric bone mineral density (vBMD) and microarchitecture of trabecular (Tb) and cortical (Ct) bone measured by high resolution peripheral quantitative computerised tomography (HRpQCT) at the distal radius and tibia and to investigate the genetic correlations of these measures. Participants were 177 mother-offspring pairs from 162 families (mothers, mean age (SD) = 52.1 (4.7) years; offspring, 25.6 (0.73) years). Trabecular and cortical bone measures were obtained by HRpQCT. Multivariable linear regression was used to analyse the association of bone measures between mother and offspring. Sequential Oligogenic Linkage Analysis Routines (SOLAR) software was utilised to conduct quantitative genetic analyses. All maternal bone measures were independently associated with the corresponding bone measures in the offspring before and after adjustment for age, sex, weight and height. Heritability estimates ranged from 24% to 67% at the radius and from 42% to 74% at the tibia. The relationship for most bone geometry measures was significantly stronger in mother-son pairs (n = 107) compared with mother-daughter pairs (n = 70) (p < 0.05). In contrast, the heritability for most vBMD and microarchitecture measures were higher in mother-daughter pairs. Bivariate analyses found moderate to strong genetic correlations across all measures between radius and tibia (Rg = 0.49 to 0.93).

Genetic factors have an important role in the development of bone geometry, vBMD and microarchitecture. These factors are strongly shared for the radius and tibia but vary by sex implying a role for imprinting.

Item Details

Item Type:Refereed Article
Keywords:bone QCT/micro CT, cortical porosity, genetic correlation, heritability, peak bone mass
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Rheumatology and arthritis
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Yang, Y (Mr Allan Yang)
UTAS Author:Pan, F (Dr Feng Pan)
UTAS Author:Wu, F (Dr Feitong Wu)
UTAS Author:Squibb, K (Dr Kathryn Squibb)
UTAS Author:Winzenberg, T (Professor Tania Winzenberg)
UTAS Author:Jones, G (Professor Graeme Jones)
ID Code:124864
Year Published:2018
Web of Science® Times Cited:9
Deposited By:Menzies Institute for Medical Research
Deposited On:2018-03-15
Last Modified:2018-12-11

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