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Stability of dobutamine in continuous ambulatory delivery devices

Citation

Al Madfai, F and Valah, B and Zaidi, STR and Wanandy, T and Ming, LC and Peterson, GM and Patel, RP, Stability of dobutamine in continuous ambulatory delivery devices, Journal of Clinical Pharmacy and Therapeutics, 43, (4) pp. 530-535. ISSN 1365-2710 (2018) [Refereed Article]

Copyright Statement

2018 John Wiley & Sons Ltd

DOI: doi:10.1111/jcpt.12674

Abstract

What is known and objective: Continuous infusion of dobutamine plays an important role in the management of patients with end-stage heart failure. Home infusion of dobutamine using a continuous ambulatory delivery device (CADD) facilitates the management of patients in their home, avoiding complications associated with long-term hospitalization. However, the stability of dobutamine in CADD is currently unknown. Therefore, this study investigated the physicochemical stability of dobutamine in CADDs at three different temperatures over various time points.

Methods: Six CADDs (three containing dobutamine 10 mg/mL in 0.9% sodium chloride and three containing dobutamine 10 mg/mL in 5% glucose) were prepared and stored at 4C for 7 days, followed by 12 hours at 35C and then for another 12 hours at 25C. An aliquot (n = 3) was withdrawn aseptically at 0, 24, 48, 72, 96, 120, 144 and 168 hours when stored at 4C, and at 0, 6 and 12 hours when stored at the other two temperatures. Each sample was analysed for dobutamine concentration using a stability-indicating high-performance liquid chromatography. All the samples were also evaluated for change in pH, colour and for particle content.

Results and discussion: No evidence of particle formation, colour or pH change was observed throughout the study period. Dobutamine, when admixed with 0.9% sodium chloride or 5% glucose, was found to be chemically stable for at least 168 hours at 4C and for another 12 hours at 35C and for another 12 hours at 25C.

What is new and conclusions: Our findings will allow health professionals to provide a weekly supply of dobutamine-containing CADDs to patients for home infusions. Continuous infusion over a 24-hour period using one CADD per day will also decrease the number of exchanges required and thus reduce the risk of catheter-related bloodstream infections.

Item Details

Item Type:Refereed Article
Keywords:dobutamine, drug stability, ambulatory infusion devices, chromatography
Research Division:Medical and Health Sciences
Research Group:Pharmacology and Pharmaceutical Sciences
Research Field:Pharmaceutical Sciences
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cardiovascular System and Diseases
UTAS Author:Al Madfai, F (Mrs Farah Al Madfai)
UTAS Author:Zaidi, STR (Dr Tabish Razi Zaidi)
UTAS Author:Wanandy, T (Mr Troy Wanandy)
UTAS Author:Ming, LC (Dr Long Ming)
UTAS Author:Peterson, GM (Professor Gregory Peterson)
UTAS Author:Patel, RP (Dr Rahul Patel)
ID Code:124850
Year Published:2018
Web of Science® Times Cited:4
Deposited By:Pharmacy
Deposited On:2018-03-14
Last Modified:2019-01-29
Downloads:0

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