Al Madfai, F and Valah, B and Zaidi, STR and Wanandy, T and Ming, LC and Peterson, GM and Patel, RP, Stability of dobutamine in continuous ambulatory delivery devices, Journal of Clinical Pharmacy and Therapeutics, 43, (4) pp. 530-535. ISSN 1365-2710 (2018) [Refereed Article]
© 2018 John Wiley & Sons Ltd
What is known and objective: Continuous infusion of dobutamine plays an important role in the management of patients with end-stage heart failure. Home infusion of dobutamine using a continuous ambulatory delivery device (CADD) facilitates the management of patients in their home, avoiding complications associated with long-term hospitalization. However, the stability of dobutamine in CADD is currently unknown. Therefore, this study investigated the physicochemical stability of dobutamine in CADDs at three different temperatures over various time points.
Methods: Six CADDs (three containing dobutamine 10 mg/mL in 0.9% sodium chloride and three containing dobutamine 10 mg/mL in 5% glucose) were prepared and stored at 4°C for 7 days, followed by 12 hours at 35°C and then for another 12 hours at 25°C. An aliquot (n = 3) was withdrawn aseptically at 0, 24, 48, 72, 96, 120, 144 and 168 hours when stored at 4°C, and at 0, 6 and 12 hours when stored at the other two temperatures. Each sample was analysed for dobutamine concentration using a stability-indicating high-performance liquid chromatography. All the samples were also evaluated for change in pH, colour and for particle content.
Results and discussion: No evidence of particle formation, colour or pH change was observed throughout the study period. Dobutamine, when admixed with 0.9% sodium chloride or 5% glucose, was found to be chemically stable for at least 168 hours at 4°C and for another 12 hours at 35°C and for another 12 hours at 25°C.
What is new and conclusions: Our findings will allow health professionals to provide a weekly supply of dobutamine-containing CADDs to patients for home infusions. Continuous infusion over a 24-hour period using one CADD per day will also decrease the number of exchanges required and thus reduce the risk of catheter-related bloodstream infections.
|Item Type:||Refereed Article|
|Keywords:||dobutamine, drug stability, ambulatory infusion devices, chromatography|
|Research Division:||Biomedical and Clinical Sciences|
|Research Group:||Pharmacology and pharmaceutical sciences|
|Research Field:||Pharmaceutical sciences|
|Objective Group:||Clinical health|
|Objective Field:||Clinical health not elsewhere classified|
|UTAS Author:||Al Madfai, F (Mrs Farah Al Madfai)|
|UTAS Author:||Zaidi, STR (Dr Tabish Razi Zaidi)|
|UTAS Author:||Wanandy, T (Mr Troy Wanandy)|
|UTAS Author:||Ming, LC (Dr Long Ming)|
|UTAS Author:||Peterson, GM (Professor Gregory Peterson)|
|UTAS Author:||Patel, RP (Dr Rahul Patel)|
|Web of Science® Times Cited:||10|
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