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Stability of cefazolin in polyisoprene elastomeric infusion devices


Patel, RP and Jacob, J and Sedeeq, M and Ming, LC and Wanandy, T and Zaidi, STR and Peterson, GM, Stability of cefazolin in polyisoprene elastomeric infusion devices, Clinical therapeutics, 40, (4) pp. 664-667. ISSN 0149-2918 (2018) [Refereed Article]

Copyright Statement

Copyright 2018 Elsevier HS Journals,Inc. All rights reserved.

DOI: doi:10.1016/j.clinthera.2018.02.009


PURPOSE: The aim was to investigate the stability of cefazolin in elastomeric infusion devices.

METHODS: Elastomeric devices (Infusor LV) that contain cefazolin (3 g/240 mL and 6 g/240 mL) were prepared and stored at 4C for 72 hours and then at 35C for 12 hours, followed by 25C for 12 hours. An aliquot was withdrawn at predefined time points and analyzed for the concentration of cefazolin. Samples were also assessed for changes in pH, solution color, and particle content.

FINDINGS: Cefazolin retained acceptable chemical and physical stability over the studied storage period and conditions.

IMPLICATIONS: These findings will allow the administration of cefazolin by the Infusor LV elastomeric device in the outpatient and remote settings.

Item Details

Item Type:Refereed Article
Keywords:cefazolin, stability, elastomeric infusion, continuous infusion, elastromeric device, high-performance liquid chromatography
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Pharmaceutical sciences
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Patel, RP (Dr Rahul Patel)
UTAS Author:Jacob, J (Associate Professor John Jacob)
UTAS Author:Sedeeq, M (Mr Mohammed Sedeeq)
UTAS Author:Ming, LC (Dr Long Ming)
UTAS Author:Wanandy, T (Mr Troy Wanandy)
UTAS Author:Zaidi, STR (Dr Tabish Razi Zaidi)
UTAS Author:Peterson, GM (Professor Gregory Peterson)
ID Code:124847
Year Published:2018
Web of Science® Times Cited:6
Deposited By:Pharmacy
Deposited On:2018-03-14
Last Modified:2019-01-29

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