File(s) under permanent embargo
Stability of cefazolin in polyisoprene elastomeric infusion devices
journal contribution
posted on 2023-05-19, 16:44 authored by Rahul PatelRahul Patel, Jacob, J, Mohammed SedeeqMohammed Sedeeq, Ming, LC, Stephanus WanandyStephanus Wanandy, Syed Razi ZaidiSyed Razi Zaidi, Gregory PetersonGregory PetersonPURPOSE: The aim was to investigate the stability of cefazolin in elastomeric infusion devices.
METHODS: Elastomeric devices (Infusor LV) that contain cefazolin (3 g/240 mL and 6 g/240 mL) were prepared and stored at 4°C for 72 hours and then at 35°C for 12 hours, followed by 25°C for 12 hours. An aliquot was withdrawn at predefined time points and analyzed for the concentration of cefazolin. Samples were also assessed for changes in pH, solution color, and particle content.
FINDINGS: Cefazolin retained acceptable chemical and physical stability over the studied storage period and conditions.
IMPLICATIONS: These findings will allow the administration of cefazolin by the Infusor LV elastomeric device in the outpatient and remote settings.
History
Publication title
Clinical therapeuticsVolume
40Issue
4Pagination
664-667ISSN
0149-2918Department/School
School of Pharmacy and PharmacologyPublisher
Excerpta Medica IncPlace of publication
650 Avenue Of The Americas, New York, USA, Ny, 10011Rights statement
Copyright 2018 Elsevier HS Journals,Inc. All rights reserved.Repository Status
- Restricted