Patel, RP and Jacob, J and Sedeeq, M and Ming, LC and Wanandy, T and Zaidi, STR and Peterson, GM, Stability of cefazolin in polyisoprene elastomeric infusion devices, Clinical therapeutics, 40, (4) pp. 664-667. ISSN 0149-2918 (2018) [Refereed Article]
Copyright 2018 Elsevier HS Journals,Inc. All rights reserved.
PURPOSE: The aim was to investigate the stability of cefazolin in elastomeric infusion devices.
METHODS: Elastomeric devices (Infusor LV) that contain cefazolin (3 g/240 mL and 6 g/240 mL) were prepared and stored at 4°C for 72 hours and then at 35°C for 12 hours, followed by 25°C for 12 hours. An aliquot was withdrawn at predefined time points and analyzed for the concentration of cefazolin. Samples were also assessed for changes in pH, solution color, and particle content.
FINDINGS: Cefazolin retained acceptable chemical and physical stability over the studied storage period and conditions.
IMPLICATIONS: These findings will allow the administration of cefazolin by the Infusor LV elastomeric device in the outpatient and remote settings.
|Item Type:||Refereed Article|
|Keywords:||cefazolin, stability, elastomeric infusion, continuous infusion, elastromeric device, high-performance liquid chromatography|
|Research Division:||Medical and Health Sciences|
|Research Group:||Pharmacology and Pharmaceutical Sciences|
|Research Field:||Pharmaceutical Sciences|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Infectious Diseases|
|UTAS Author:||Patel, RP (Dr Rahul Patel)|
|UTAS Author:||Jacob, J (Associate Professor John Jacob)|
|UTAS Author:||Sedeeq, M (Mr Mohammed Sedeeq)|
|UTAS Author:||Ming, LC (Dr Long Ming)|
|UTAS Author:||Wanandy, T (Mr Troy Wanandy)|
|UTAS Author:||Zaidi, STR (Dr Tabish Razi Zaidi)|
|UTAS Author:||Peterson, GM (Professor Gregory Peterson)|
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