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Low intensity repetitive transcranial magnetic stimulation modulates skilled motor learning in adult mice

Citation

Tang, AD and Bennett, W and Hadrill, C and Collins, J and Fulopova, B and Wills, K and Bindoff, A and Puri, R and Garry, MI and Hinder, MR and Summers, JJ and Rodger, J and Canty, AJ, Low intensity repetitive transcranial magnetic stimulation modulates skilled motor learning in adult mice, Scientific Reports, 8 Article 4016. ISSN 2045-2322 (2018) [Refereed Article]


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Copyright Statement

Copyright 2018 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

Official URL: https://www.nature.com/articles/s41598-018-22385-8

DOI: doi:10.1038/s41598-018-22385-8

Abstract

Repetitive transcranial magnetic stimulation (rTMS) is commonly used to modulate cortical plasticity in clinical and non-clinical populations. Clinically, rTMS is delivered to targeted regions of the cortex at high intensities (>1 T). We have previously shown that even at low intensities, rTMS induces structural and molecular plasticity in the rodent cortex. To determine whether low intensity rTMS (LI-rTMS) alters behavioural performance, daily intermittent theta burst LI-rTMS (120 mT) or sham was delivered as a priming or consolidating stimulus to mice completing 10 consecutive days of skilled reaching training. Relative to sham, priming LI-rTMS (before each training session), increased skill accuracy (~9%) but did not alter the rate of learning over time. In contrast, consolidating LI-rTMS (after each training session), resulted in a small increase in the rate of learning (an additional ~1.6% each day) but did not alter the daily skill accuracy. Changes in behaviour with LI-rTMS were not accompanied with long lasting changes in brain-derived neurotrophic factor (BDNF) expression or in the expression of plasticity markers at excitatory and inhibitory synapses for either priming or consolidation groups. These results suggest that LI-rTMS can alter specific aspects of skilled motor learning in a manner dependent on the timing of intervention.

Item Details

Item Type:Refereed Article
Keywords:transcranial magnetic stimulation, non-invasive brain stimulation, theta burst stimulation
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Neurosciences not elsewhere classified
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:Bennett, W (Dr Bill Bennett)
Author:Hadrill, C (Ms Claire Hadrill)
Author:Collins, J (Miss Jessica Collins)
Author:Fulopova, B (Mrs Barbora Fulopova)
Author:Wills, K (Dr Karen Wills)
Author:Bindoff, A (Mr Aidan Bindoff)
Author:Puri, R (Mr Rohan Puri)
Author:Garry, MI (Dr Michael Garry)
Author:Hinder, MR (Dr Mark Hinder)
Author:Summers, JJ (Professor Jeffery Summers)
Author:Canty, AJ (Associate Professor Alison Canty)
ID Code:124835
Year Published:2018
Deposited By:Riawunna
Deposited On:2018-03-14
Last Modified:2018-04-11
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