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Low intensity repetitive transcranial magnetic stimulation modulates skilled motor learning in adult mice
Citation
Tang, AD and Bennett, W and Hadrill, C and Collins, J and Fulopova, B and Wills, K and Bindoff, A and Puri, R and Garry, MI and Hinder, MR and Summers, JJ and Rodger, J and Canty, AJ, Low intensity repetitive transcranial magnetic stimulation modulates skilled motor learning in adult mice, Scientific Reports, 8 Article 4016. ISSN 2045-2322 (2018) [Refereed Article]
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Copyright Statement
Copyright 2018 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/
Official URL: https://www.nature.com/articles/s41598-018-22385-8
DOI: doi:10.1038/s41598-018-22385-8
Abstract
Repetitive transcranial magnetic stimulation (rTMS) is commonly used to modulate cortical plasticity in clinical and non-clinical populations. Clinically, rTMS is delivered to targeted regions of the cortex at high intensities (>1 T). We have previously shown that even at low intensities, rTMS induces structural and molecular plasticity in the rodent cortex. To determine whether low intensity rTMS (LI-rTMS) alters behavioural performance, daily intermittent theta burst LI-rTMS (120 mT) or sham was delivered as a priming or consolidating stimulus to mice completing 10 consecutive days of skilled reaching training. Relative to sham, priming LI-rTMS (before each training session), increased skill accuracy (~9%) but did not alter the rate of learning over time. In contrast, consolidating LI-rTMS (after each training session), resulted in a small increase in the rate of learning (an additional ~1.6% each day) but did not alter the daily skill accuracy. Changes in behaviour with LI-rTMS were not accompanied with long lasting changes in brain-derived neurotrophic factor (BDNF) expression or in the expression of plasticity markers at excitatory and inhibitory synapses for either priming or consolidation groups. These results suggest that LI-rTMS can alter specific aspects of skilled motor learning in a manner dependent on the timing of intervention.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | transcranial magnetic stimulation, non-invasive brain stimulation, theta burst stimulation |
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Neurosciences |
| Research Field: | Neurosciences not elsewhere classified |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Clinical health not elsewhere classified |
| UTAS Author: | Bennett, W (Dr Bill Bennett) |
| UTAS Author: | Hadrill, C (Ms Claire Hadrill) |
| UTAS Author: | Collins, J (Dr Jessica Collins) |
| UTAS Author: | Fulopova, B (Mrs Barbora Fulopova) |
| UTAS Author: | Wills, K (Dr Karen Wills) |
| UTAS Author: | Bindoff, A (Mr Aidan Bindoff) |
| UTAS Author: | Puri, R (Mr Rohan Puri) |
| UTAS Author: | Garry, MI (Dr Michael Garry) |
| UTAS Author: | Hinder, MR (Associate Professor Mark Hinder) |
| UTAS Author: | Summers, JJ (Professor Jeffery Summers) |
| UTAS Author: | Canty, AJ (Associate Professor Alison Canty) |
| ID Code: | 124835 |
| Year Published: | 2018 |
| Web of Science® Times Cited: | 11 |
| Deposited By: | Riawunna |
| Deposited On: | 2018-03-14 |
| Last Modified: | 2021-04-08 |
| Downloads: | 127 View Download Statistics |
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