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Total synthesis of (±)-dihydroisosubamol

journal contribution
posted on 2023-05-19, 16:38 authored by Pflasterer, D, Rudolph, M, Brian YatesBrian Yates, Alireza AriafardAlireza Ariafard, Hashmi, ASK
We herein report the first total synthesis of the dibenzocycloheptanoide (±)-dihydroisosubamol. The key step includes a recently developed gold-catalysed hydroarylation reaction for the construction of the dibenzocycloheptene motif. Additional steps are a Suzuki-Miyaura cross coupling, a palladium-catalysed hydroxylation and an allylic oxidation. To access the saturated seven-membered ring system an iridium-catalysed hydrogenation proved to be successful.

History

Publication title

Advanced Synthesis and Catalysis

Volume

359

Issue

5

Pagination

866-874

ISSN

1615-4150

Department/School

School of Natural Sciences

Publisher

Wiley-V C H Verlag Gmbh

Place of publication

Po Box 10 11 61, Weinheim, Germany, D-69451

Rights statement

Copyright 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Repository Status

  • Restricted

Socio-economic Objectives

Expanding knowledge in the chemical sciences

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