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Total synthesis of (±)-dihydroisosubamol
journal contribution
posted on 2023-05-19, 16:38 authored by Pflasterer, D, Rudolph, M, Brian YatesBrian Yates, Alireza AriafardAlireza Ariafard, Hashmi, ASKWe herein report the first total synthesis of the dibenzocycloheptanoide (±)-dihydroisosubamol. The key step includes a recently developed gold-catalysed hydroarylation reaction for the construction of the dibenzocycloheptene motif. Additional steps are a Suzuki-Miyaura cross coupling, a palladium-catalysed hydroxylation and an allylic oxidation. To access the saturated seven-membered ring system an iridium-catalysed hydrogenation proved to be successful.
History
Publication title
Advanced Synthesis and CatalysisVolume
359Issue
5Pagination
866-874ISSN
1615-4150Department/School
School of Natural SciencesPublisher
Wiley-V C H Verlag GmbhPlace of publication
Po Box 10 11 61, Weinheim, Germany, D-69451Rights statement
Copyright 2017 Wiley-VCH Verlag GmbH & Co. KGaA, WeinheimRepository Status
- Restricted