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The impact of mild heat stress during prolonged running on gastrointestinal integrity, gastrointestinal symptoms, systemic endotoxin and cytokine profiles

Citation

Snipe, RMJ and Khoo, A and Kitic, CM and Gibson, PR and Costa, RJS, The impact of mild heat stress during prolonged running on gastrointestinal integrity, gastrointestinal symptoms, systemic endotoxin and cytokine profiles, International Journal of Sports Medicine, 39, (4) pp. 255-263. ISSN 0172-4622 (2018) [Refereed Article]

Copyright Statement

Georg Thieme Verlag KG Stuttgart New York

DOI: doi:10.1055/s-0043-122742

Abstract

The study aimed to determine the effects of mild exertional heat stress on intestinal injury, permeability, gastrointestinal symptoms, and systemic endotoxin and cytokine responses. Ten endurance runners completed 2 h of running at 60% V̇O2max in warm (WARM: 30C) and temperate (TEMP: 22C) ambient conditions. Rectal temperature (Tre) and gastrointestinal symptoms were recorded every 10 min during exercise. Blood samples were collected pre- and post-exercise, and during recovery to determine plasma intestinal fatty acid-binding protein (I-FABP) and cortisol concentrations, and systemic endotoxin and inflammatory cytokine profiles. Urinary lactulose:L-rhamnose ratio (L/R) was used to measure small intestine permeability. Compared with TEMP, WARM significantly increased Tre from 50 min onwards (38.10.3C vs. 38.40.5C, respectively; p<0.01), gastrointestinal symptoms (p=0.017), post-exercise plasma cortisol (26% vs. 59%, respectively; p<0.001) and I-FABP (127% vs. 184%, respectively; p<0.001) concentrations. Circulatory anti-endotoxin antibodies increased post-exercise (p<0.001) on WARM (20%) and TEMP (28%). No differences were observed for plasma endotoxin concentration (6% vs. 5% increase, respectively) or small intestine permeability (L/R 0.0260.010 and 0.0250.015, respectively). Both pro- and anti-inflammatory cytokines increased post-exercise, with inflammatory response cytokines TNF-α (p=0.015) and IL-8 (p=0.044), and compensatory anti-inflammatory cytokines IL-10 (p=0.065), and IL-1ra higher on WARM than TEMP. Findings suggest that exposure to warm ambient conditions during prolonged submaximal running induces transient intestinal epithelial injury, increases gastrointestinal symptoms, and promotes greater perturbations to the systemic cytokine profile compared to running in temperate conditions.

Item Details

Item Type:Refereed Article
Keywords:heat, endurance, permeability, I-FABP, symptoms, gastrointestinal syndrome
Research Division:Medical and Health Sciences
Research Group:Human Movement and Sports Science
Research Field:Human Movement and Sports Science not elsewhere classified
Objective Division:Health
Objective Group:Specific Population Health (excl. Indigenous Health)
Objective Field:Specific Population Health (excl. Indigenous Health) not elsewhere classified
UTAS Author:Kitic, CM (Dr Cecilia Kitic)
ID Code:124669
Year Published:2018
Web of Science® Times Cited:9
Deposited By:Health Sciences
Deposited On:2018-03-03
Last Modified:2018-11-28
Downloads:0

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