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Obesity and multiple sclerosis: Prevalence, susceptibility and progression in disability
Citation
Tettey, P and Balogun, S, Obesity and multiple sclerosis: Prevalence, susceptibility and progression in disability, Future Neurology, 12, (3) pp. 149-157. ISSN 1479-6708 (2017) [Refereed Article]
Copyright Statement
Copyright 2017 Future Medicine Ltd
DOI: doi:10.2217/fnl-2017-0012
Abstract
Recent emerging data indicate that obesity is an important risk factor for multiple sclerosis (MS) susceptibility and may be associated with MS disability progression. Marked interactions between obesity and human leukocyte antigen (HLA) genotype with regard to the risk of MS have been reported. Evidence from Mendelian randomization studies also point to a causal relationship between obesity and MS risk. In this report, we aimed to analyze the current evidence of the relationship between obesity and risk of MS and disability progression, examine data on the interaction between obesity and HLA risk genes of MS and Mendelian randomization studies and to explore the plausible biological mechanisms that may underlie this relationship.
Item Details
Item Type: | Refereed Article |
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Keywords: | body mass index, disability progression, human leukocyte antigen, Mendelian randomization, multiple sclerosis, obesity, prevalence, susceptibility |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Neurosciences |
Research Field: | Central nervous system |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Tettey, P (Mr Prudence Tettey) |
UTAS Author: | Balogun, S (Dr Saliu Balogun) |
ID Code: | 124604 |
Year Published: | 2017 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2018-02-28 |
Last Modified: | 2022-08-29 |
Downloads: | 0 |
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