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Uteroglobin and FLRG concentrations in aqueous humor are associated with age in primary open angle glaucoma patients

Citation

Ashworth Briggs, EL and Toh, T and Eri, R and Hewitt, A and Cook, AL, Uteroglobin and FLRG concentrations in aqueous humor are associated with age in primary open angle glaucoma patients, BMC ophthalmology, 18, (1) pp. 1-8. ISSN 1471-2415 (2018) [Refereed Article]


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Copyright 2018 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

DOI: doi:10.1186/s12886-018-0723-4

Abstract

Background: The pathophysiological changes occurring in the trabecular meshwork in primary open angle glaucoma are poorly understood, but are thought to include increased extracellular matrix deposition, trabecular meshwork cell apoptosis, inflammation, trabecular meshwork calcification and altered protein composition of the aqueous humor. Although many proteins are present in aqueous humor, relatively few have been studied extensively, and their potential roles in primary open angle glaucoma are unknown.

Methods: Analyte concentrations in aqueous humor from 19 primary open angle glaucoma and 18 cataract patients were measured using a multiplex immunoassay. Fisherís exact test was used to assess statistical significance between groups, and correlations of analyte concentrations with age, intraocular pressure, pattern standard deviation, mean deviation, cup-to-disc ratio and disease duration since commencing treatment were tested by Spearmanís method.

Results: CHI3L1, FLRG, HGF, MIF, P-selectin and Uteroglobin were detected in more than 50% of samples of one or both patient groups, some of which have not previously been quantified in aqueous humor. In the glaucoma but not the cataract group, significant correlations were determined with age for Uteroglobin/SCGB1A1 (rs = 0.805, p < 0.0001) and FLRG (rs = 0.706, p = 0.0007). Furthermore, HGF correlated significantly with disease duration (rs = − 0.723, p = 0.0007). There were no differences in analyte concentrations between groups, and no other significant associations with clinical descriptors that passed correction for multiple testing.

Conclusions: The correlations of uteroglobin and FLRG with age in primary open angle glaucoma but not cataract may suggest a heightened requirement for anti-inflammatory (uteroglobin) or anti-calcification (FLRG) activity in the ageing glaucomatous trabecular meshwork.

Item Details

Item Type:Refereed Article
Keywords:primary open angle glaucoma, trabecular meshwork, aqueous humor, uteroglobin/SCGB1A1, FLRG
Research Division:Medical and Health Sciences
Research Group:Ophthalmology and Optometry
Research Field:Optometry and Ophthalmology not elsewhere classified
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Neurodegenerative Disorders Related to Ageing
Author:Ashworth Briggs, EL (Mrs Esther Ashworth Briggs)
Author:Eri, R (Associate Professor Raj Eri)
Author:Hewitt, A (Professor Alex Hewitt)
Author:Cook, AL (Dr Tony Cook)
ID Code:124580
Year Published:2018
Deposited By:Wicking Dementia Research and Education Centre
Deposited On:2018-02-28
Last Modified:2018-04-12
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