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Association between human herpesvirus & human endogenous retrovirus and MS onset & progression
journal contribution
posted on 2023-05-19, 16:17 authored by Tao, C, Steve Simpson JRSteve Simpson JR, Bruce TaylorBruce Taylor, Ingrid van der MeiIngrid van der MeiThis review discusses the role of Epstein-Barr virus (EBV), human herpesvirus 6 (HHV6) and human endogenous retroviruses (HERVs) in the onset and progression of multiple sclerosis (MS). Although EBV has been established as one of the causal factors in MS onset, its role in MS progression is still uncertain. Moreover, interactions between EBV and other risk factor on MS development still need more investment. With less consistent evidence than EBV, HHV6 has also been implicated in the pathogenesis of MS; moreover, it showed a closer connection with the disease activity. Recent studies found that HERVs were associated with the development and progression of MS. Some antiviral treatments have shown promise for clinical interventions in the future. Future studies are yet needed to fully clarify the role of these agents in MS onset and disease course and the modes by which they realise these effects.
History
Publication title
Journal of the Neurological SciencesVolume
372Pagination
239-249ISSN
0022-510XDepartment/School
Menzies Institute for Medical ResearchPublisher
Elsevier Science BvPlace of publication
Po Box 211, Amsterdam, Netherlands, 1000 AeRights statement
© 2016 Elsevier B.V. All rights reserved.Repository Status
- Restricted