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Association between human herpesvirus & human endogenous retrovirus and MS onset & progression

Citation

Tao, C and Simpson Jr, S and Taylor, BV and van der Mei, I, Association between human herpesvirus & human endogenous retrovirus and MS onset & progression, Journal of the Neurological Sciences, 372 pp. 239-249. ISSN 0022-510X (2017) [Refereed Article]

Copyright Statement

2016 Elsevier B.V. All rights reserved.

DOI: doi:10.1016/j.jns.2016.11.060

Abstract

This review discusses the role of Epstein-Barr virus (EBV), human herpesvirus 6 (HHV6) and human endogenous retroviruses (HERVs) in the onset and progression of multiple sclerosis (MS). Although EBV has been established as one of the causal factors in MS onset, its role in MS progression is still uncertain. Moreover, interactions between EBV and other risk factor on MS development still need more investment. With less consistent evidence than EBV, HHV6 has also been implicated in the pathogenesis of MS; moreover, it showed a closer connection with the disease activity. Recent studies found that HERVs were associated with the development and progression of MS. Some antiviral treatments have shown promise for clinical interventions in the future. Future studies are yet needed to fully clarify the role of these agents in MS onset and disease course and the modes by which they realise these effects.

Item Details

Item Type:Refereed Article
Keywords:Epstein-Barr virus, human endogenous retroviruses, human herpesvirus 6, multiple sclerosis, onset, progression
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Central Nervous System
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:Tao, C (Mr Chunrong Tao)
Author:Simpson Jr, S (Dr Steve Simpson JR)
Author:Taylor, BV (Professor Bruce Taylor)
Author:van der Mei, I (Associate Professor Ingrid van der Mei)
ID Code:124427
Year Published:2017
Web of Science® Times Cited:5
Deposited By:Menzies Institute for Medical Research
Deposited On:2018-02-21
Last Modified:2018-08-13
Downloads:0

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