Wang, K and Xu, J and Cai, J and Zheng, S and Yang, X and Ding, C, Serum levels of resistin and interleukin-17 are associated with increased cartilage defects and bone marrow lesions in patients with knee osteoarthritis, Modern Rheumatology, 27, (2) pp. 339-344. ISSN 1439-7595 (2017) [Refereed Article]
Copyright 2016 Japan College of Rheumatology
Methods: One hundred and ninety-four consecutively-selected patients with knee symptomatic OA (mean 55.4 years, range 34-74, 87% females) were included in Anhui Osteoarthritis (AHOA) Study. Knee cartilage defects and BMLs were determined at different sites using T2-weighted fat-suppressed fast spin echo MRI. Serum resistin, IL-17, and high-sensitivity C-reactive protein (hs-CRP) levels were measured using ELISA.
Results: In multivariable analyses, serum resistin was positively associated with cartilage defects at lateral femoral, lateral tibial, and medial tibial (all p < 0.05) sites. The significant associations were also present with BMLs at lateral femoral and tibial sites (ORs: 1.13-1.19, both p < 0.05). In patients with the highest quartile of hs-CRP (>2.45 pg/ml), IL-17 was positively and significantly associated with cartilage defect score at nearly all sites (ORs: 1.33-1.44, all p < 0.05), and BMLs at lateral and medial femoral sites (ORs: 1.26-1.51, both p < 0.05).
Conclusions: Serum levels of resistin were positively and independently associated with cartilage defects and BMLs in patients with knee OA. Serum IL-17 was significantly associated with cartilage defects and BMLs in patients with an increased inflammatory status. These suggest that metabolic and inflammatory mechanisms may have a role to play in knee OA.
|Item Type:||Refereed Article|
|Keywords:||bone, cartilage, Interleukin-17, osteoarthritis, resistin|
|Research Division:||Medical and Health Sciences|
|Research Group:||Clinical Sciences|
|Research Field:||Rheumatology and Arthritis|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Skeletal System and Disorders (incl. Arthritis)|
|Author:||Zheng, S (Miss Shuang Zheng)|
|Author:||Ding, C (Professor Chang-Hai Ding)|
|Web of Science® Times Cited:||5|
|Deposited By:||Menzies Institute for Medical Research|
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