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Calcium influx pathways in breast cancer: opportunities for pharmacological intervention


Azimi, I and Roberts-Thomson, SJ and Monteith, GR, Calcium influx pathways in breast cancer: opportunities for pharmacological intervention, British Journal of Pharmacology, 171, (4) pp. 945-60. ISSN 0007-1188 (2014) [Refereed Article]

Copyright Statement

Copyright 2013 The British Pharmacological Society

DOI: doi:10.1111/bph.12486


Ca(2+) influx through Ca(2+) permeable ion channels is a key trigger and regulator of a diverse set of cellular events, such as neurotransmitter release and muscle contraction. Ca(2+) influx is also a regulator of processes relevant to cancer, including cellular proliferation and migration. This review focuses on calcium influx in breast cancer cells as well as the potential for pharmacological modulators of specific Ca(2+) influx channels to represent future agents for breast cancer therapy. Altered expression of specific calcium permeable ion channels is present in some breast cancers. In some cases, such changes can be related to breast cancer subtype and even prognosis. In vitro and in vivo models have now helped identify specific Ca(2+) channels that play important roles in the proliferation and invasiveness of breast cancer cells. However, some aspects of our understanding of Ca(2+) influx in breast cancer still require further study. These include identifying the mechanisms responsible for altered expression and the most effective therapeutic strategy to target breast cancer cells through specific Ca(2+) channels. The role of Ca(2+) influx in processes beyond breast cancer cell proliferation and migration should become the focus of studies in the next decade.

Item Details

Item Type:Refereed Article
Keywords:Calcium influx pathways in breast cancer: opportunities for pharmacological intervention
Research Division:Biomedical and Clinical Sciences
Research Group:Oncology and carcinogenesis
Research Field:Cancer cell biology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Azimi, I (Dr Iman Azimi)
ID Code:124410
Year Published:2014
Web of Science® Times Cited:98
Deposited By:Pharmacy
Deposited On:2018-02-21
Last Modified:2018-03-16

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