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Plasma membrane ion channels and epithelial to mesenchymal transition in cancer cells
Citation
Azimi, I and Monteith, GR, Plasma membrane ion channels and epithelial to mesenchymal transition in cancer cells, Endocrine-related cancer, 23, (11) pp. R517-R525. ISSN 1351-0088 (2016) [Refereed Article]
Copyright Statement
Copyright 2016 Society for Endocrinology
Abstract
A variety of studies have suggested that epithelial to mesenchymal transition (EMT) may be important in the progression of cancer in patients through metastasis and/or therapeutic resistance. A number of pathways have been investigated in EMT in cancer cells. Recently, changes in plasma membrane ion channel expression as a consequence of EMT have been reported. Other studies have identified specific ion channels able to regulate aspects of EMT induction. The utility of plasma membrane ion channels as targets for pharmacological modulation make them attractive for therapeutic approaches to target EMT. In this review, we provide an overview of some of the key plasma membrane ion channel types and highlight some of the studies that are beginning to define changes in plasma membrane ion channels as a consequence of EMT and also their possible roles in EMT induction.
Item Details
Item Type: | Refereed Article |
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Keywords: | Plasma membrane ion channels and epithelial to mesenchymal transition in cancer cells |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Clinical sciences |
Research Field: | Medical genetics (excl. cancer genetics) |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Azimi, I (Dr Iman Azimi) |
ID Code: | 124407 |
Year Published: | 2016 |
Web of Science® Times Cited: | 25 |
Deposited By: | Pharmacy |
Deposited On: | 2018-02-21 |
Last Modified: | 2018-03-16 |
Downloads: | 0 |
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