The interplay between hypoxia-inducible factor-1 (HIF-1) and calcium in cancer has begun to be unravelled with recent findings demonstrating the relationships between the two in different cancer types. This is an area of significance considering the crucial roles of both HIF-1 and calcium signalling in cancer progression and metastasis. This review summarises the experimental evidence of the crosstalk between HIF-1 and specific calcium channels, pumps and regulators in the context of cancer. HIF-1 as a master regulator of hypoxic transcriptional responses, mediates transcription of several calcium modulators. On the other hand, specific calcium channels and pumps regulate HIF-1 activity through controlling its transcription, translation, stabilisation, or nuclear translocation. Identifying the interplay between HIF-1 and components of the calcium signal will give new insights into mechanisms underlying cellular responses to physiological and pathophysiological cues, and may provide novel and more efficient therapeutic strategies for the control of cancer progression.

Item Type:	Refereed Article
Keywords:	HIF-1, calcium signalling, cancer
Research Division:	Biological Sciences
Research Group:	Biochemistry and cell biology
Research Field:	Signal transduction
Objective Division:	Health
Objective Group:	Clinical health
Objective Field:	Clinical health not elsewhere classified
UTAS Author:	Azimi, I (Dr Iman Azimi)
ID Code:	124400
Year Published:	2018
Web of Science® Times Cited:	23
Deposited By:	Pharmacy
Deposited On:	2018-02-21
Last Modified:	2019-12-03
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