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1α,25-Dihydroxyvitamin D3 up-regulates IL-34 expression in SH-SY5Y neural cells


Zhang, D and Li, M and Dong, Y and Zhang, X and Liu, X and Chen, Z and Zhu, Y and Wang, H and Liu, X and Zhu, J and Shen, Y and Korner, H and Ying, S and Fang, S and Shen, Y, 1α,25-Dihydroxyvitamin D3 up-regulates IL-34 expression in SH-SY5Y neural cells, Innate Immunity, 23, (7) pp. 584-591. ISSN 1753-4259 (2017) [Refereed Article]

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Copyright 2017 The Authors

DOI: doi:10.1177/1753425917725391


Vitamin D supplementation is regarded as a novel approach to treat Alzheimer's disease, but the underlying mechanism remains elusive. The cytokine IL-34 provides strong neuroprotective and survival signals in brain injury and neurodegeneration and could be an immunological mediator for the vitamin D-induced protection. The aim of this study was to investigate whether human IL-34 is up-regulated in neuronal cells by the hormonally active form of vitamin D, 1α,25-dihydroxyvitamin D3 [1α,25(OH)2D3]. We found that IL-34 was detectable in a variety of cell lines and its expression was strongly induced in SH-SY5Y neural cells in a dose- and time-dependent manner by 1α,25(OH)2D3 through the vitamin D receptor (VDR). Furthermore, we identified the core promoter of IL-34 gene and a VDR binding site (CGCCCT) that was required for 1α,25(OH)2D3-induced IL-34 expression. These findings suggest that the induction of IL-34 expression by 1α,25(OH)2D3 may constitute a mechanism that explains the protective function of vitamin D in Alzheimer's disease.

Item Details

Item Type:Refereed Article
Keywords:1α, 25-Dihydroxyvitamin D3, Alzheimer disease, IL-34, expression, neuronal cell
Research Division:Biomedical and Clinical Sciences
Research Group:Immunology
Research Field:Immunology not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Korner, H (Professor Heinrich Korner)
ID Code:124391
Year Published:2017
Web of Science® Times Cited:11
Deposited By:Menzies Institute for Medical Research
Deposited On:2018-02-21
Last Modified:2018-07-20

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