Beauchet, O and Blumen, HM and Callisaya, ML and De Cock, A-M and Kressig, RW and Srikanth, V and Steinmetz, J-P and Verghese, J and Allali, G, Spatiotemporal gait characteristics associated with cognitive impairment: A multicenter cross-sectional study, the Intercontinental 'Gait, cOgnitiOn & Decline' initiative, Current Alzheimer Research, 15, (3) pp. 273-282. ISSN 1567-2050 (2018) [Refereed Article]
© 2018 Bentham Science Publishers
Methods: A total of 2099 participants (1015 CHI, 478 patients with MCI, 331 patients with mild dementia and 275 with moderate dementia) were selected from the intercontinental "Gait, cOgnitiOn & Decline" (GOOD) initiative, which merged different databases from seven cross-sectional studies. Mean values and coefficients of variation (CoV) of spatiotemporal gait parameters were recorded during usual walking with the GAITRite® system.
Results: The severity of cognitive impairment was associated with worse performance on all gait parameters. Stride velocity had the strongest association with cognitive impairment, regardless of cognitive status. High mean value and CoV of stride length characterized moderate dementia, whereas increased CoV of stride time was specific to MCI status.
Conclusion: The findings support the existence of specific cognitive impairment-related gait disturbances with differences related to stages of cognitive impairment, which may be used to screen individuals with cognitive impairment.
|Item Type:||Refereed Article|
|Keywords:||epidemiology, gait disorders, motor control, cognitive disorders, gait assessment, Alzheimer’s disease|
|Research Division:||Biomedical and Clinical Sciences|
|Research Group:||Clinical sciences|
|Research Field:||Geriatrics and gerontology|
|Objective Group:||Specific population health (excl. Indigenous health)|
|Objective Field:||Health related to ageing|
|UTAS Author:||Callisaya, ML (Dr Michele Callisaya)|
|Web of Science® Times Cited:||10|
|Deposited By:||Menzies Institute for Medical Research|
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