eCite Digital Repository
Association of depression with evolution of heart failure in patients with type 2 diabetes mellitus
Citation
Wang, Y and Yang, H and Nolan, M and Burgess, J and Negishi, K and Marwick, TH, Association of depression with evolution of heart failure in patients with type 2 diabetes mellitus, Cardiovascular Diabetology, 17, (1) Article 19. ISSN 1475-2840 (2018) [Refereed Article]
![]() | PDF 978Kb |
Copyright Statement
© The Author(s) 2018. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) http://creativecommons.org/licenses/by/4.0/
DOI: doi:10.1186/s12933-018-0664-5
Abstract
Methods: We prospectively recruited 274 asymptomatic T2DM patients ≥ 65 years (age 71 ± 4 year, 56% men) with preserved EF and no ischemic heart disease from a community-based population. The Patient Health Questionnaire 9 (PHQ-9) was used to detect depression, and LV dysfunction was sought with a comprehensive echocardiogram, including LV hypertrophy (LVH) and subclinical diastolic function (E/e'). Over a median follow-up of 1.5 years (range 0.5-3), 20 patients were lost to follow-up and 254 individuals were followed for outcomes.
Results: At baseline, depression was present in 9.5%, LVH was identified in 26% and reduced E/e' in 11%. Over a median follow-up of 1.5 years, 37 of 245 patients developed new-onset HF and 3 died, giving an event rate of 107/1000 person-years. In a competing-risks regression analysis, depression (adjusted HR 2.54, 95% CI 1.18-5.46; p = 0.017) was associated with incident HF and had incremental predictive power to clinical, biochemical and echocardiographic variables.
Conclusion: Depression is prevalent in asymptomatic elderly patients with T2DM, and depression independently and incrementally predicts incident HF.
Item Details
Item Type: | Refereed Article |
---|---|
Keywords: | depression, incident heart failure, type 2 diabetes mellitus |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Clinical sciences |
Research Field: | Endocrinology |
Objective Division: | Health |
Objective Group: | Clinical health |
Objective Field: | Clinical health not elsewhere classified |
UTAS Author: | Wang, Y (Ms Ying Wang) |
UTAS Author: | Yang, H (Ms Hilda Yang) |
UTAS Author: | Nolan, M (Mr Mark Nolan) |
UTAS Author: | Burgess, J (Professor John Burgess) |
UTAS Author: | Negishi, K (Dr Kazuaki Negishi) |
UTAS Author: | Marwick, TH (Professor Tom Marwick) |
ID Code: | 124253 |
Year Published: | 2018 |
Web of Science® Times Cited: | 15 |
Deposited By: | Medicine |
Deposited On: | 2018-02-14 |
Last Modified: | 2022-08-30 |
Downloads: | 89 View Download Statistics |
Repository Staff Only: item control page