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The optimal dosage regimen of vitamin D supplementation for correcting deficiency in adolescents: a pilot randomized controlled trial


Wu, F and Xiao, C and Aitken, D and Jones, G and Winzenberg, T, The optimal dosage regimen of vitamin D supplementation for correcting deficiency in adolescents: a pilot randomized controlled trial, European Journal of Clinical Nutrition, 72, (4) pp. 534-540. ISSN 0954-3007 (2018) [Refereed Article]

Copyright Statement

Copyright 2018 Macmillan Publishers Limited, part of Springer Nature

DOI: doi:10.1038/s41430-018-0098-x


Background/Objectives: Vitamin D deficiency is common in adolescents but the optimal dosage regimen for correcting deficiency is unknown. To test the safety and efficacy of two different vitamin D dosage regimens to correct vitamin D deficiency in adolescents.

Subjects/Methods: In this 12-month, double-blind, randomized placebo-controlled trial, 28 adolescents (serum 25 hydroxyvitamin D (25(OH)D) of 21 to 50 nmol/L) were randomly assigned to one of three groups: monthly (n = 9; vitamin D3 50,000 IU orally monthly plus three placebo tablets 3-monthly), 3-monthly (n = 9; 150,000 IU (3  50,000 IU tablets) 3-monthly and placebo orally monthly), or placebo (n = 10; placebo monthly and three placebo tablets 3-monthly). Serum 25(OH)D was measured at baseline, 3, 6 and 12 months.

Results: Two participants withdrew after their baseline measurement from the 3-monthly group. At 12 months, one participant was deficient (≤50 nmol/L) in both the monthly and 3-monthly groups, whereas six out of ten in the placebo remained deficient (P = 0.055). At 12 months, the average serum 25(OH)D levels for the monthly, 3-monthly and placebo groups were 76.4, 64.7 and 49.7 nmol/L, respectively (P < 0.001 and P = 0.04 for differences between monthly and placebo groups and 3-monthly and placebo groups respectively, after adjustment for age, sex and seasonal variation). Adherence was 100% and adverse events were minor.

Conclusions: Both 50,000 IU monthly and 150,000 IU 3-monthly of vitamin D3 safely and effectively corrects vitamin D deficiency in adolescents. These data provide treatment options which can be used by health practitioners to tailor vitamin D dosage regiments according to patient preference and context.

Item Details

Item Type:Refereed Article
Keywords:vitamin D, supplementation, adolescents
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Rheumatology and arthritis
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Wu, F (Dr Feitong Wu)
UTAS Author:Xiao, C (Ms Cecilia Xiao)
UTAS Author:Aitken, D (Associate Professor Dawn Aitken)
UTAS Author:Jones, G (Professor Graeme Jones)
UTAS Author:Winzenberg, T (Professor Tania Winzenberg)
ID Code:124207
Year Published:2018
Deposited By:Menzies Institute for Medical Research
Deposited On:2018-02-13
Last Modified:2018-12-11

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