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Longitudinal associations between serum 25-hydroxyvitamin D, physical activity, knee pain and dysfunction and physiological falls risk in community-dwelling older adults

Citation

Balogun, S and Winzenberg, T and Wills, K and Scott, D and Jones, G and Callisaya, M and Aitken, D, Longitudinal associations between serum 25-hydroxyvitamin D, physical activity, knee pain and dysfunction and physiological falls risk in community-dwelling older adults, Experimental Gerontology, 104 pp. 72-77. ISSN 0531-5565 (2018) [Refereed Article]

Copyright Statement

Copyright 2018 Elsevier Inc.

DOI: doi:10.1016/j.exger.2018.01.026

Abstract

Aims: To describe the longitudinal associations between physiological falls risk, and between-person and within-person effects of 25-hydroxyvitamin D (25OHD), physical activity (PA), knee pain and dysfunction in community-dwelling older people.

Methods: Data for 1053 participants (51% women; mean age 63  7.4 years) studied at baseline, 2.5, 5, and 10 years were analysed. Falls risk (Z-score) was measured using the Physiological Profile Assessment. Knee pain and dysfunction were assessed using the Western Ontario and McMaster Universities Osteoarthritis index (WOMAC). Moderate-to-vigorous PA (MVPA) was measured using accelerometer. Linear mixed-effect regression models, with adjustment for confounders, were used to estimate the association between physiological falls risk and between-person and within-person effects of PA, 25OHD and WOMAC score.

Results: Between-person effects showed that 10-year average physiological falls risk was lower in participants who had a higher 10-year average 25OHD (β = -0.005 per nmol/l, 95% CI: -0.008, -0.002), log-MVPA (β = -0.16 per minute, 95% CI: -0.22, -0.10) and lower mean WOMAC score (β = 0.005 per-unit score, 95% CI: 0.003, 0.01). Within-person effects showed that a higher physiological falls risk at any time-point was associated with higher than average WOMAC score (β = 0.002 per-unit score, 95% CI: 0.0003, 0.004) and lower than average log-MVPA (β = -0.15 per minute, 95% CI: -0.24, -0.06), but not 25OHD, at the same time-point.

Conclusion: Having higher WOMAC global score above an individual's average increases the risk of falling, whereas, increasing one's own MVPA level further reduces their risk of falling. The presence of between-person but not within-person associations for 25OHD suggests the former may be confounded by other factors.

Item Details

Item Type:Refereed Article
Keywords:falls, pain, physical activity, vitamin D
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Rheumatology and Arthritis
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
UTAS Author:Balogun, S (Dr Saliu Balogun)
UTAS Author:Winzenberg, T (Professor Tania Winzenberg)
UTAS Author:Wills, K (Dr Karen Wills)
UTAS Author:Jones, G (Professor Graeme Jones)
UTAS Author:Callisaya, M (Dr Michele Callisaya)
UTAS Author:Aitken, D (Associate Professor Dawn Aitken)
ID Code:124205
Year Published:2018
Web of Science® Times Cited:2
Deposited By:Menzies Institute for Medical Research
Deposited On:2018-02-13
Last Modified:2018-12-11
Downloads:0

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