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Early exercise intervention ameliorates the detrimental impact of maternal obesity


Caruso, V and Bahari, H and Morris, MJ, Early exercise intervention ameliorates the detrimental impact of maternal obesity, Obesity Research & Clinical Practice, pp. 34. ISSN 1871-403X (2011) [Conference Extract]

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DOI: doi:10.1016/j.orcp.2011.08.120


Aim: To examine the effects of an early exercise intervention on male offspring of obese mothers consuming either chow (C) or a high fat chow diet (F).

Method: Adult female Sprague Dawley rats were fed either C or F ad libitum for 5 weeks, then were mated with C fed males and remained on their respective diet during gestation and lactation. At day 20, males from each litter were separated into C or F fed groups in the presence or absence of voluntary exercise wheels, yielding 4 groups. At 10 weeks of age, the running wheel was removed. At 15 weeks of age, rats were euthanased for tissue and plasma collection.

Results: At weaning, pups from F mothers were 29% heavier than those from C mothers. At 15 weeks, fasting plasma insulin level was significantly reduced by exercise (49%) in offspring of F mothers consuming F, compared to those remaining sedentary and consuming the same diet. Exercise reduced body weight (BW) in rats of F mothers consuming C (−18%) but not F (−1%) as well as total fat mass (−65%).

Conclusions: Exercise in early life had long lasting beneficial effects on the BW, adipose mass and hormone profile of male offspring from obese mothers. This was observed after 5 weeks without exercise suggesting that early exercise may prevent subsequent weight gain due to later sedentary lifestyle. Thus, an early exercise intervention might have a protective effect on the adult metabolic profile following maternal obesity.

Item Details

Item Type:Conference Extract
Keywords:Obesity, maternal imprinting, exercise
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Pharmacology and pharmaceutical sciences not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Caruso, V (Dr Vanni Caruso)
ID Code:123805
Year Published:2011
Deposited By:Pharmacy
Deposited On:2018-01-29
Last Modified:2018-03-27

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