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The positive effects of fucoidans extracted from the brown seaweed Saccharina japonica on protection against CCl4-induced liver injury

Citation

Song, Y and Wang, Q and He, Y and Ren, D and Kow, F and Li, J and Liu, S and Cong, H, The positive effects of fucoidans extracted from the brown seaweed Saccharina japonica on protection against CCl4-induced liver injury, Journal of Applied Phycology, 29, (4) pp. 2077-2087. ISSN 0921-8971 (2017) [Refereed Article]


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DOI: doi:10.1007/s10811-017-1097-3

Abstract

Fucoidan is a sulphated polysaccharide derived from brown algae that contains a variety of bioactive compounds. The brown alga Saccharina japonica is an abundant bioresource for the commercialization of fucoidan, which has been aquacultured on a large scale in China. To explore the hepatoprotective effect of fucoidans from S. japonica, the seaweeds were extracted using an enzymolysis protocol, and a crude extract (F) was obtained by ethanol precipitation. Then, F was subjected to diethylaminoethyl (DEAE) column chromatography, and three fractions (F1, F2, and F3) were collected. The fundamental characteristics, including the monosaccharide composition and the structural features of F1F3, were investigated using high-performance liquid chromatography (HPLC), Fourier transform infrared (FTIR), and nuclear magnetic resonance (NMR) spectroscopy. F1 and F2 were rich in galactose and mannuronic acid, respectively, in addition to containing fucose. F3 mainly consisted of sulphated fucopyranose. All three fractions showed in vitro antioxidative activity against the hydroxyl radical. The hepatoprotective activities of F1F3 were evaluated. Mice were orally administered fucoidans for 1 week and then intraperitoneally injected with CCl4. Four hepatoprotective indicators were analysed to evaluate the efficacy of the three preparations. A high dose of F3 (300500 mg kg−1 day−1) caused a significant difference in all four indicators compared to the control without fucoidan; this result was confirmed by histological examination of the mouse liver tissues. These results suggest that fucoidans from S. japonica had potential as ingredients for functional foods or pharmaceuticals to prevent liver injury.

Item Details

Item Type:Refereed Article
Keywords:fucoidans, seaweed, liver injury, brown algae
Research Division:Biological Sciences
Research Group:Plant Biology
Research Field:Phycology (incl. Marine Grasses)
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Biological Sciences
Author:Kow, F (Dr Felicia Kow)
ID Code:123550
Year Published:2017
Deposited By:Ecology and Biodiversity
Deposited On:2018-01-11
Last Modified:2018-01-11
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