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Integrated modeling of survival data from multiple stressor ecotoxicology experiments

Citation

Proctor, AH and King, CK and Holan, JR and Wotherspoon, SJ, Integrated modeling of survival data from multiple stressor ecotoxicology experiments, Environmental Science and Technology, 51, (12) pp. 7271-7277. ISSN 0013-936X (2017) [Refereed Article]


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DOI: doi:10.1021/acs.est.7b02255

Abstract

Ecotoxicological assessments often focus on the response of an organism to an individual contaminant under standardized laboratory conditions. Under more ecologically realistic conditions, however, individuals are likely to be exposed to a range of environmental conditions that have the potential to act as additional stressors. Multiple-stressor experiments improve our understanding of an organismís response to a toxicant under ecologically relevant conditions and provide realistic risk assessment data. To date, there is no standardized method for analyzing multiple-stressor data using dose-response regression. We present a reliable technique to assess for the effects of additional stressors on an LCx estimate in a consistent framework, providing interpretable results that meaningfully deal with environmental changes and their possible impacts on sensitivity estimates to a toxicant. The method is applicable to any data set where toxicity tests are conducted at varying levels of one or more additional stressors. We illustrate the method with data from an experiment that investigates the effects of salinity and temperature on the sensitivity of the subantarctic isopod Limnoria stephenseni to copper, where it is shown that the major change in the LC50 can be primarily attributed to a specific temperature increase. This method has been incorporated into an R package available at github.com/ahproctor/LC50.

Item Details

Item Type:Refereed Article
Keywords:ecotoxicology, multiple stressors, toxicity testing, survival data
Research Division:Chemical Sciences
Research Group:Other Chemical Sciences
Research Field:Environmental Chemistry (incl. Atmospheric Chemistry)
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Environmental Sciences
Author:Proctor, AH (Mrs Abigael Proctor)
Author:Wotherspoon, SJ (Dr Simon Wotherspoon)
ID Code:123544
Year Published:2017
Web of Science® Times Cited:1
Deposited By:Ecology and Biodiversity
Deposited On:2018-01-11
Last Modified:2018-01-11
Downloads:0

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