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Time of day and short-duration high-intensity exercise influences on coagulation and fibrinolysis

Citation

Zadow, EK and Kitic, CM and Wu, SSX and Fell, JW and Adams, MJ, Time of day and short-duration high-intensity exercise influences on coagulation and fibrinolysis, European journal of sport science, 18, (3) pp. 367-375. ISSN 1536-7290 (2018) [Refereed Article]

Copyright Statement

Copyright 2018 European College of Sport Science

DOI: doi:10.1080/17461391.2017.1420237

Abstract

Exercise has been demonstrated to have considerable effects upon haemostasis, with activation dependent upon the duration and intensity of the exercise bout. In addition, markers of coagulation and fibrinolysis have been shown to possess circadian rhythms, peaking within the morning (0600-1200 h). Therefore, the time of day in which exercise is performed may influence the activation of the coagulation and fibrinolytic systems. This study aimed to examine coagulation and fibrinolytic responses to short-duration high-intensity exercise when completed at different times of the day. Fifteen male cyclists (VO2max: 60.3  8.1 ml kg-1 min-1) completed a 4-km cycling time trial (TT) on five separate occasions at 0830, 1130, 1430, 1730 and 2030. Venous blood samples were obtained pre- and immediately post-exercise, and analysed for tissue factor (TF), tissue factor pathway inhibitor (TFPI), thrombin-anti-thrombin complexes (TAT) and D-Dimer. Exercise significantly increased plasma concentrations of TF (p < .0005), TFPI (p < .0006), TAT complexes (p < .0012) and D-Dimer (p < .0003). There was a time-of-day effect in pre-exercise TF (p = .004) and TFPI (p = .031), with 0830 greater than 1730 (p  .001), while 1730 was less than 2030 h (p = .008), respectively. There was no significant effect of time of day for TAT (p = .364) and D-Dimer (p = .228). Power output, TT time and heart rate were not significantly different between TTs (p > .05); however, percentage VO2max was greater at 1730 when compared to 2030 (p = .04). Due to a time-of-day effect present within TF, peaking at 0830, caution should be applied when prescribing short-duration high-intensity exercise bout within the morning in populations predisposed to hypercoagulability.

Item Details

Item Type:Refereed Article
Keywords:Thrombin, anti-thrombin III, D-dimer, circadian rhythm, cycling, KICKR
Research Division:Medical and Health Sciences
Research Group:Human Movement and Sports Science
Research Field:Human Movement and Sports Science not elsewhere classified
Objective Division:Health
Objective Group:Specific Population Health (excl. Indigenous Health)
Objective Field:Specific Population Health (excl. Indigenous Health) not elsewhere classified
Author:Zadow, EK (Ms Emma Zadow)
Author:Kitic, CM (Dr Cecilia Kitic)
Author:Wu, SSX (Dr Sam Wu)
Author:Fell, JW (Associate Professor James Fell)
Author:Adams, MJ (Dr Murray Adams)
ID Code:123536
Year Published:2018
Deposited By:Health Sciences
Deposited On:2018-01-11
Last Modified:2018-05-08
Downloads:0

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