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The interaction between vitamin D receptor polymorphisms and sun exposure around time of diagnosis influences melanoma survival
Citation
Orlow, I and Shi, Y and Kanetsky, PA and Thomas, NE and Luo, L and Corrales-Guerrero, S and Cust, AE and Sacchetto, L and Zanetti, R and Rosso, S and Armstrong, BK and Dwyer, T and Venn, A and Gallagher, RP and Gruber, SB and Marrett, LD and Anton-Culver, H and Busam, K and Begg, CB and Berwick, M, The interaction between vitamin D receptor polymorphisms and sun exposure around time of diagnosis influences melanoma survival, Pigment Cell and Melanoma Research pp. 1-10. ISSN 1755-1471 (2018) [Refereed Article]
Copyright Statement
Copyright 2017 John Wiley & Sons A/S
Abstract
Evidence on the relationship between the vitamin D pathway and outcomes in melanoma is growing, although it is not always clear. We investigated the impact of measured levels of sun exposure at diagnosis on associations of vitamin D receptor gene (VDR) polymorphisms and melanoma death in 3336 incident primary melanoma cases. Interactions between six SNPs and a common 3'-end haplotype were significant (p < .05). These SNPs, and a haplotype, had a statistically significant association with survival among subjects exposed to high UVB in multivariable regression models and exerted their effect in the opposite direction among those with low UVB. SNPs rs1544410/BsmI and rs731236/TaqI remained significant after adjustment for multiple testing. These results suggest that the association between VDR and melanoma-specific survival is modified by sun exposure around diagnosis, and require validation in an independent study. Whether the observed effects are dependent or independent of vitamin D activation remains to be determined.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | exposure, haplotype, interaction, melanoma, polymorphism, SNP, survival, UVB, vitamin D receptor |
| Research Division: | Health Sciences |
| Research Group: | Epidemiology |
| Research Field: | Epidemiology not elsewhere classified |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Clinical health not elsewhere classified |
| UTAS Author: | Venn, A (Professor Alison Venn) |
| ID Code: | 123523 |
| Year Published: | 2018 (online first 2017) |
| Web of Science® Times Cited: | 10 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2018-01-10 |
| Last Modified: | 2018-08-28 |
| Downloads: | 0 |
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