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The interaction between vitamin D receptor polymorphisms and sun exposure around time of diagnosis influences melanoma survival

Citation

Orlow, I and Shi, Y and Kanetsky, PA and Thomas, NE and Luo, L and Corrales-Guerrero, S and Cust, AE and Sacchetto, L and Zanetti, R and Rosso, S and Armstrong, BK and Dwyer, T and Venn, A and Gallagher, RP and Gruber, SB and Marrett, LD and Anton-Culver, H and Busam, K and Begg, CB and Berwick, M, The interaction between vitamin D receptor polymorphisms and sun exposure around time of diagnosis influences melanoma survival, Pigment Cell and Melanoma Research pp. 1-10. ISSN 1755-1471 (2018) [Refereed Article]

Copyright Statement

Copyright 2017 John Wiley & Sons A/S

DOI: doi:10.1111/pcmr.12653

Abstract

Evidence on the relationship between the vitamin D pathway and outcomes in melanoma is growing, although it is not always clear. We investigated the impact of measured levels of sun exposure at diagnosis on associations of vitamin D receptor gene (VDR) polymorphisms and melanoma death in 3336 incident primary melanoma cases. Interactions between six SNPs and a common 3'-end haplotype were significant (p < .05). These SNPs, and a haplotype, had a statistically significant association with survival among subjects exposed to high UVB in multivariable regression models and exerted their effect in the opposite direction among those with low UVB. SNPs rs1544410/BsmI and rs731236/TaqI remained significant after adjustment for multiple testing. These results suggest that the association between VDR and melanoma-specific survival is modified by sun exposure around diagnosis, and require validation in an independent study. Whether the observed effects are dependent or independent of vitamin D activation remains to be determined.

Item Details

Item Type:Refereed Article
Keywords:exposure, haplotype, interaction, melanoma, polymorphism, SNP, survival, UVB, vitamin D receptor
Research Division:Medical and Health Sciences
Research Group:Public Health and Health Services
Research Field:Epidemiology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cancer and Related Disorders
Author:Venn, A (Professor Alison Venn)
ID Code:123523
Year Published:2018 (online first 2017)
Deposited By:Menzies Institute for Medical Research
Deposited On:2018-01-10
Last Modified:2018-08-28
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