File(s) under permanent embargo
The interaction between vitamin D receptor polymorphisms and sun exposure around time of diagnosis influences melanoma survival
journal contribution
posted on 2023-05-19, 14:50 authored by Orlow, I, Shi, Y, Kanetsky, PA, Thomas, NE, Luo, L, Corrales-Guerrero, S, Cust, AE, Sacchetto, L, Zanetti, R, Rosso, S, Armstrong, BK, Dwyer, T, Alison VennAlison Venn, Gallagher, RP, Gruber, SB, Marrett, LD, Anton-Culver, H, Busam, K, Begg, CB, Berwick, MEvidence on the relationship between the vitamin D pathway and outcomes in melanoma is growing, although it is not always clear. We investigated the impact of measured levels of sun exposure at diagnosis on associations of vitamin D receptor gene (VDR) polymorphisms and melanoma death in 3336 incident primary melanoma cases. Interactions between six SNPs and a common 3'-end haplotype were significant (p < .05). These SNPs, and a haplotype, had a statistically significant association with survival among subjects exposed to high UVB in multivariable regression models and exerted their effect in the opposite direction among those with low UVB. SNPs rs1544410/BsmI and rs731236/TaqI remained significant after adjustment for multiple testing. These results suggest that the association between VDR and melanoma-specific survival is modified by sun exposure around diagnosis, and require validation in an independent study. Whether the observed effects are dependent or independent of vitamin D activation remains to be determined.
History
Publication title
Pigment Cell and Melanoma ResearchPagination
1-10ISSN
1755-1471Department/School
Menzies Institute for Medical ResearchPublisher
Wiley-Blackwell Publishing, Inc.Place of publication
United StatesRights statement
Copyright 2017 John Wiley & Sons A/SRepository Status
- Restricted