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Expression of membrane-bound CC chemokine ligand 20 on follicular T helper cells in T-B-cell conjugates

Citation

Lee, AYS and Reimer, D and Zehrer, A and Lu, M and Mielenz, D and Korner, H, Expression of membrane-bound CC chemokine ligand 20 on follicular T helper cells in T-B-cell conjugates, Frontiers in Immunology, 8 Article 1871. ISSN 1664-3224 (2017) [Refereed Article]


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Copyright Statement

2017 Lee et al. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

DOI: doi:10.3389/fimmu.2017.01871

Abstract

The CC chemokine receptor 6 (CCR6) and its sole chemokine ligand CC chemokine ligand 20 (CCL20) display an emerging role in the coordination of humoral immune responses. Recent studies demonstrate a role of this chemokine axis in the migration of B cells to key immunological sites during an immune response, and facilitating the generation of high-quality antibodies. Very little, however, is known about CCL20 and its role in these functions. We undertook a preliminary investigation into the expression and function of CCL20 and demonstrate its well-noted upregulation in the spleen during immunization. Furthermore, we show that most follicular T helper (Tfh) cells can be CCR6 + and can produce CCL20. Surprisingly, CCL20 cannot only be found in the cytoplasm but also on the surface of these cells and their precursors. Analysis of T-B-cell conjugates revealed that mature Tfh cells, but not their precursors, are highly enriched in the conjugates. Further functional studies are needed to unravel the precise role of CCL20 in coordinating T and B cell interactions during the humoral immune response.

Item Details

Item Type:Refereed Article
Keywords:TB cell communication, CC chemokine ligand 20, CC chemokine receptor 6, humoral immune response, T cells
Research Division:Medical and Health Sciences
Research Group:Immunology
Research Field:Immunology not elsewhere classified
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Infectious Diseases
Author:Lee, AYS (Dr Adrian Lee)
Author:Zehrer, A (Ms Annette Zehrer)
Author:Lu, M (Dr Ming Lu)
Author:Korner, H (Professor Heinrich Korner)
ID Code:123502
Year Published:2017
Deposited By:Menzies Institute for Medical Research
Deposited On:2018-01-10
Last Modified:2018-03-07
Downloads:11 View Download Statistics

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