Aerosol-Based Detectors in Liquid Chromatography: Approaches Toward Universal Detection and to Global Analysis

© 2017 John Wiley & Sons, Inc. All rights reserved. This chapter discusses the various types of universal detection techniques that can be used in Liquid Chromatography (LC). It also discusses the advantages and disadvantages of aerosol detectors with particular reference to the factors that affect analyte response in these detectors and efforts that have been made to characterize these effects. Due to their inherent mode of operation, aerosol detectors are compatible with a wide range of volatile solvents consistent with the principles of green chemistry and allow these detectors to be hyphenated to a wide range of liquid chromatographic methods, including high temperature water and supercritical carbon dioxide chromatographic separations. Aerosol detectors are discussed in the context of global analysis and their use in combination with multidimensional separations. It discusses one of the approaches to overcoming the gradient effect to develop empirical models that relate detector response to both the composition of the mobile phase and the amount of analyte injected.